Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics
Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics
复制标题
DOI：
10.1152/ajpheart.00590.2011
复制
发表时间：
2012-05-01
影响因子：
4.8
通讯作者：
Albrecht, Eugene D.
中科院分区：
文献类型：
--
作者：
Aberdeen, Graham W.;Bonagura, Thomas W.;Albrecht, Eugene D.
引用本文：Aberdeen GW， Bonagura TW, Harman CR, Pepe GJ, Albrecht ED.雌激素对狒狒妊娠期间滋养细胞子宫螺旋动脉重构的影响。[J] .中华心脏杂志，2012,31(2):336 - 344。首次发表于2012年3月16日；doi: 10.1152 / ajpheart.00590.2011。本研究旨在确定在狒狒怀孕前三个月通过过早提高雌激素水平来抑制子宫螺旋动脉滋养细胞重塑对子宫和脐带血流动力学的影响。在妊娠第25-59天给予雌二醇抑制子宫螺旋动脉重构的狒狒，在妊娠第60、100和160天（妊娠期：184天）急性给予生理盐水（基础状态）和血清素后，用多普勒超声评估子宫胎盘血流。妊娠早期给予雌二醇的狒狒，在第160天，母体基础血压升高（P < 0.01），子宫动脉舒张切痕和反映下游血流阻抗的脐动脉脉搏指数和收缩压/舒张比升高（P < 0.01）。在5 -羟色胺和雌二醇处理的小鼠中，子宫胎盘血流动力学的变化伴随着子宫和脐动脉容积流量和胎儿心动过缓的减少（P < 0.05）。本研究结果表明，在灵长类动物妊娠晚期血管挑战后，通过促进妊娠中期至妊娠早期雌激素的升高来抑制子宫动脉重塑，会破坏子宫胎盘血流动力学和胎儿稳态。
Aberdeen GW, Bonagura TW, Harman CR, Pepe GJ, Albrecht ED. Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics. Am J Physiol Heart Circ Physiol 302: H1936-H1944, 2012. First published March 16, 2012; doi: 10.1152/ajpheart.00590.2011.-The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal state) and serotonin on days 60, 100, and 160 of gestation (term: 184 days) to baboons in which uterine spiral artery remodeling had been suppressed by the administration of estradiol on days 25-59 of gestation. Maternal blood pressure in the basal state was increased (P < 0.01), and uterine artery diastolic notching and the umbilical artery pulsatility index and systolic-to-diastolic ratio, reflecting downstream flow impedance, were increased (P < 0.01) after serotonin administration on day 160, but not earlier, in baboons treated with estradiol in early gestation. These changes in uteroplacental flow dynamics in serotonin-infused, estradiol-treated animals were accompanied by a decrease (P < 0.05) in uterine and umbilical artery volume flow and fetal bradycardia. The results of this study show that suppression of uterine artery remodeling by advancing the rise in estrogen from the second trimester to the first trimester disrupted uteroplacental blood flow dynamics and fetal homeostasis after vasochallenge late in primate pregnancy.