Cutting edge:: CD83 regulates the development of cellular immunity
Cutting edge:: CD83 regulates the development of cellular immunity
复制标题
DOI：
10.4049/jimmunol.168.6.2599
复制
发表时间：
2002-03-15
影响因子：
4.4
通讯作者：
Ledbetter, JA
中科院分区：
文献类型：
--
作者：
Scholler, N;Hayden-Ledbetter, M;Ledbetter, JA
我们最近发现，人类成熟树突状细胞的标志物CD83是一种粘附受体，可与静止的单核细胞和活化的CD8(+) T细胞亚群结合。我们将CD83-Ig注射到移植了免疫原性P815肥大细胞瘤的小鼠体内，发现它显著提高了肿瘤的生长速度，抑制了细胞毒性T细胞的发育。相比之下，用cd83转染的K1735细胞（一种免疫原性较差的黑色素瘤）免疫小鼠，可以阻止野生型K1735细胞的生长。体外对人PBL的研究表明，共固定CD83-Ig和抗cd3可增强T细胞的增殖，增加CD8(+) T细胞的比例。在MLR培养中，转染cd83的b淋巴母细胞T51细胞比未转染的T51细胞更有效地刺激T细胞增殖，并增加细胞溶解性T细胞的产生。我们得出结论，CD83是一种功能重要的受体，可以通过与其配体相互作用来调节细胞免疫的发展。
We recently found that human CD83, a marker of mature dendritic cells, is an adhesion receptor that binds to resting monocytes and a subset of activated CD8(+) T cells. We injected CD83-Ig into mice transplanted with the immunogenic P815 mastocytoma and showed that it significantly enhanced the rate of tumor growth and inhibited the development of cytotoxic T cells. In contrast, mice Immunized with CD83-transfected K1735 cells, a poorly immunogenic melanoma, could prevent the outgrowth of wild-type K1735 cells. Studies performed in vitro with human PBL showed that coimmobilized CD83-Ig and anti-CD3 enhanced T cell proliferation and increased the proportion of CD8(+) T cells. CD83-transfected B-lymphoblastoid T51 cells stimulated T cell proliferation more effectively than untransfected T51 cells in MLR cultures and increased the generation of cytolytic T cells. We conclude that CD83 is a functionally important receptor that can regulate the development of cellular immunity by interacting with its ligand(s).