MIRA: an R package for DNA methylation-based inference of regulatory activity.

MIRA: an R package for DNA methylation-based inference of regulatory activity.
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DOI:
10.1093/bioinformatics/bty083
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发表时间:
2018-08-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
Sheffield NC
Sheffield NC
中科院分区:
其他
文献类型:
--
作者:
Lawson JT;Tomazou EM;Bock C;Sheffield NC

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DNA甲基化包含有关细胞调控状态的信息。MIRA将基因组尺度的DNA甲基化数据聚合到具有共享生物注释的给定区域集的DNA甲基化谱中。使用这个概要,MIRA推断并评分区域集合的集体监管活动。MIRA促进了在经典调控分析困难的情况下的调控分析,并允许利用区域集的公共来源对DNA甲基化数据集的调控状态进行新的见解。http://bioconductor.org/packages/MIRA。
DNA methylation contains information about the regulatory state of the cell. MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation. Using this profile, MIRA infers and scores the collective regulatory activity for the region set. MIRA facilitates regulatory analysis in situations where classical regulatory assays would be difficult and allows public sources of region sets to be leveraged for novel insight into the regulatory state of DNA methylation datasets. http://bioconductor.org/packages/MIRA.
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