Hyperspectral imaging in systemic sclerosis-associated Raynaud phenomenon.
Hyperspectral imaging in systemic sclerosis-associated Raynaud phenomenon.
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DOI：
10.1186/s13075-023-02990-3
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发表时间：
2023-01-20
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
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缺乏可靠、可行和定量的结果阻碍了系统性硬化症（SSc）患者的雷诺现象（RP）临床试验。高光谱成像（HSI）非侵入性地测量皮肤中的氧合和脱氧血红蛋白（oxyHb和deoxyHb）浓度和氧饱和度（O2 sat），并将数据描绘为氧合热图。本研究探讨了HSI在量化SSc-RP疾病严重程度和活动性中的潜在作用。在临床环境中前瞻性招募SSc-RP患者（n = 13）和健康对照参与者（HC; n = 12）。使用手持相机，在温控室（22 °C）中进行双侧手HSI（HyperMed™，Waltham，MA）。计算腹侧指尖和手掌78 mm 2感兴趣区域的OxyHb、deoxyHb和O2 sat值（用于标准化）。受试者接受冷激发试验（戴手套的手浸没在15 °C水浴中1分钟），并在0、10和20分钟时重复进行HSI。患者完成两项患者报告结局（PRO）工具：雷诺状况评分（RCS）和Cochin手功能量表（CHFS）用于症状负担评估。使用Mann-Whitney U检验和混合效应模型（Stata，学院站，TX）进行统计分析。92%的参与者是40多岁的女性。对于SSc-RP患者，69%有局限性皮肤SSc，平均± SD SSc持续时间为11 ± 5年，38%有既往指溃疡-目前无。与HC相比，SSc患者的基线deoxyHb较高，O2 sat较低（p < 0.05）。SSc患者的oxyHb和O2 sat从基线到时间0（冷激发后）的下降幅度更大，与HC相比，具有明显的复温oxyHb、O2 sat和deoxyHb轨迹（p < 0.01）。冷刺激后oxyHb、deoxyHb和O2 sat水平变化与RCS或CHFS评分之间无显著相关性。高光谱成像是临床上SSc-RP定量的可行方法。RCS和CHFS值与HSI参数无关。我们的数据表明，用于评估SSc-RP在基线和冷激发反应的HSI技术是SSc-RP严重程度和活动的潜在定量测量，但需要进行评估变化敏感性的纵向研究。
Lack of robust, feasible, and quantitative outcomes impedes Raynaud phenomenon (RP) clinical trials in systemic sclerosis (SSc) patients. Hyperspectral imaging (HSI) non-invasively measures oxygenated and deoxygenated hemoglobin (oxyHb and deoxyHb) concentrations and oxygen saturation (O2 sat) in the skin and depicts data as oxygenation heatmaps. This study explored the potential role of HSI in quantifying SSc-RP disease severity and activity. Patients with SSc-RP (n = 13) and healthy control participants (HC; n = 12) were prospectively recruited in the clinic setting. Using a hand-held camera, bilateral hand HSI (HyperMed™, Waltham, MA) was performed in a temperature-controlled room (22 °C). OxyHb, deoxyHb, and O2 sat values were calculated for 78-mm2 regions of interest for the ventral fingertips and palm (for normalization). Subjects underwent a cold provocation challenge (gloved hand submersion in 15 °C water bath for 1 min), and repeated HSI was performed at 0, 10, and 20 min. Patients completed two patient-reported outcome (PRO) instruments: the Raynaud Condition Score (RCS) and the Cochin Hand Function Scale (CHFS) for symptom burden assessment. Statistical analyses were performed using the Mann-Whitney U test and a mixed effects model (Stata, College Station, TX). Ninety-two percent of participants were women in their 40s. For SSc-RP patients, 69% had limited cutaneous SSc, the mean ± SD SSc duration was 11 ± 5 years, and 38% had prior digital ulcers—none currently. Baseline deoxyHb was higher, and O2 sat was lower, in SSc patients versus HC (p < 0.05). SSc patients had a greater decline in oxyHb and O2 sat from baseline to time 0 (after cold challenge) with distinct rewarming oxyHb, O2 sat, and deoxyHb trajectories versus HCs (p < 0.01). There were no significant correlations between oxyHb, deoxyHb, and O2 sat level changes following cold challenge and RCS or CHFS scores. Hyperspectral imaging is a feasible approach for SSc-RP quantification in the clinic setting. The RCS and CHFS values did not correlate with HSI parameters. Our data suggest that HSI technology for the assessment of SSc-RP at baseline and in response to cold provocation is a potential quantitative measure for SSc-RP severity and activity, though longitudinal studies that assess sensitivity to change are needed.
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影响因子：
168.9
作者：
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