PKB/Akt signaling in heart development and disease.
PKB/Akt signaling in heart development and disease.
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DOI：
10.2741/e207
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发表时间：
2010-06
期刊：
影响因子：
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通讯作者：
Z. Chang;Qi Xiao;Qiuting Feng;Zhongzhou Yang
中科院分区：
文献类型：
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作者：
Z. Chang;Qi Xiao;Qiuting Feng;Zhongzhou Yang
在哺乳动物中，存在三种Akt/PKB B（蛋白激酶B）同种型，称为Akt 1/PKB α、Akt 2/PKB β和Akt 3/PKB γ（下文称为Akt），其由位于不同染色体上的三种不同基因编码。虽然这三种Akt蛋白具有高度同源性并显示出相似的结构域结构，但小鼠遗传研究表明它们在发育和生理学中发挥重叠但不同的作用。本文综述了Akt信号在心脏发育和疾病中的作用，并讨论了Akt信号与心脏早期特化的关键信号通路的关系。Kenneth沃尔什小组对Akt在心肌细胞中的功能进行的开创性工作在新千年首次报道，因此，现在是回顾过去十年Akt在心脏生物学中作用的一些发现的正确时机。
In mammals, there are three Akt/PKB (protein kinase B) isoforms termed Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma (hereafter referred to as Akt) that are encoded by three distinct genes localized on different chromosomes. Although the three Akt proteins share high homology and display similar domain structures, mouse genetic studies have demonstrated that they play over-lapping but also differential roles in development and physiology. In this review, we summarize recent advances in understanding the roles of Akt signaling in heart development and disease, together with discussion on Akt signaling connection to key signaling pathways in early cardiac specification. The pioneering work on Akt's function in cardiomyocytes performed by Kenneth Walsh's group, was first reported in the new millennium and thus, it is now the right time to look back at some of the discoveries of Akt's role in cardiac biology over the past decade.