Stellate cells drive maturation of the entorhinal-hippocampal circuit
Stellate cells drive maturation of the entorhinal-hippocampal circuit
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DOI：
10.1126/science.aai8178
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发表时间：
2017-03-17
期刊：
影响因子：
56.9
通讯作者：
Moser, Edvard I.
中科院分区：
文献类型：
--
作者：
Donato, Flavio;Jacobsen, R. Irene;Moser, Edvard I.
空间的神经表征依赖于内鼻-海马细胞类型的网络，其放电模式根据环境的不同抽象特征进行调整。为了确定这个网络是如何在出生后早期发育过程中建立的，我们监测了发育中小鼠的结构成熟标志物，包括幼稚动物和特定细胞群的时间限制性药物遗传学沉默后。我们发现，内嗅星状细胞提供了一个活动依赖性的指导信号，驱动成熟顺序和单向通过内嗅海马网络的内在电路。这些发现提出了一种可能性，即少数自主发育的神经元群体作为大脑皮层广泛区域成熟的内在驱动因素。
The neural representation of space relies on a network of entorhinal-hippocampal cell types with firing patterns tuned to different abstract features of the environment. To determine how this network is set up during early postnatal development, we monitored markers of structural maturation in developing mice, both in naive animals and after temporally restricted pharmacogenetic silencing of specific cell populations. We found that entorhinal stellate cells provide an activity-dependent instructive signal that drives maturation sequentially and unidirectionally through the intrinsic circuits of the entorhinal-hippocampal network. The findings raise the possibility that a small number of autonomously developing neuronal populations operate as intrinsic drivers of maturation across widespread regions of the cortex.