Role of wall tension in hypoxic responses of isolated rat pulmonary arteries
Role of wall tension in hypoxic responses of isolated rat pulmonary arteries
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DOI：
10.1152/ajplung.1998.275.6.l1069
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发表时间：
1998-12-01
影响因子：
4.9
通讯作者：
Marshall, BE
中科院分区：
文献类型：
--
作者：
Ozaki, M;Marshall, C;Marshall, BE
的变化迫使发达国家在40分钟曝光缺氧(37 + / - 1毫米汞柱)记录在大(0.84 + / - 0.02毫米直径)和小(0.39 + / - 0.01毫米直径)肺内的动脉在机械的组合墙伸展紧张局势(被动+主动肌原性的组件),相当于5的透壁的血管压力,15日,30日,50和100毫米汞柱,和活跃(血管收缩)紧张,刺激PGF(2α)的剂量的0,25岁,50岁和75%有效浓度。第一分钟内所有动脉均收缩；然而，在任何主动张力下，随后的响应模式是拉伸张力的函数。在5、15和30 mmHg时，收缩在5分钟时略有下降，然后再次增加，并在整个过程中保持收缩。在50和100 mmHg时，开始收缩，随后持续扩张。当机械拉伸壁张力等于15或30 mmHg， PGF（2 α）剂量为25%或50%有效浓度时，观察到的缺氧收缩反应与体内和体外肺中观察到的反应最相似。这些观察结果调和了以前报道的许多明显矛盾的结果。
The changes in force developed during 40-min exposures to hypoxia (37 +/- 1 mmHg) were recorded in large (0.84 +/- 0.02-mm-diameter) and small(0.39 +/- 0.01-mm-diameter) intrapulmonary arteries during combinations of mechanical wall stretch tensions (passive + active myogenic components), equivalent to transmural vascular pressures of 5, 15, 30, 50, and 100 mmHg, and active (vasoconstriction) tensions, stimulated by PGF(2 alpha) in doses of 0, 25, 50, and 75% effective concentrations. Constriction was observed in all arteries during the first minute; however, at any active tension, the pattern of the subsequent response was a function of the stretch tension. At 5, 15, and 30 mmHg, the constriction decreased slightly at 5 min and then increased again to remain constrictor throughout. At 50 and 100 mmHg, the initial constriction was followed by persistent dilation. Hypoxic constrictor responses, most resembling those observed in lungs in vivo and in vitro were observed when the mechanical stretch wall tension was equivalent to 15 or 30 mmHg and the dose of PGF(2 alpha) was 25 or 50% effective concentration. These observations reconcile many apparently contradictory results reported previously.