THE HUMAN TYPE-C RETROVIRUS, HTLV, IN BLACKS FROM THE CARIBBEAN REGION, AND RELATIONSHIP TO ADULT T-CELL LEUKEMIA LYMPHOMA
THE HUMAN TYPE-C RETROVIRUS, HTLV, IN BLACKS FROM THE CARIBBEAN REGION, AND RELATIONSHIP TO ADULT T-CELL LEUKEMIA LYMPHOMA
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DOI：
10.1002/ijc.2910300302
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
GALLO, RC
中科院分区：
文献类型：
--
作者：
BLATTNER, WA;KALYANARAMAN, VS;GALLO, RC
人类T细胞白血病/淋巴瘤病毒（HTLV）是一种C型RNA肿瘤病毒，是第一种与特定类型的人类白血病/淋巴瘤相关的人类病毒。报告了加勒比地区黑人中的一组成人T细胞白血病/淋巴瘤，其中8例均为HTLV病毒和/或抗体阳性。这些患者的疾病似乎与日本成人T细胞白血病/淋巴瘤难以区分，后者在90%以上的病例中也与HTLV相关。在加勒比地区的一些正常人群中发现HTLV抗体，以及在这些病毒流行地区聚集特定形式的T细胞白血病/淋巴瘤，表明HTLV感染可能与独特的临床病理实体的发生有关。
Human T cell leukemia/lymphoma virus (HTLV) is a type-C RNA tumor virus, the first human virus of this class consistently identified in association with a specific type of human leukemia/lymphoma. A cluster of adult T cell leukemia/lymphoma among Blacks from the Caribbean is reported in which all 8 cases are positive for HTLV virus and/or antibody. These patients have disease that appears indistinguishable from Japanese adult T cell leukemia/lymphoma which is also associated with HTLV in over 90% of cases. The finding of HTLV antibodies in some of the normal population in the Caribbean, and the clustering of a specific form of T cell leukemia/lymphoma in these virus-endemic areas, suggest that HTLV infection may be associated with the occurrence of a distinctive clinico-pathologic entity.