Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: implication of defective natural killer T cells.
Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: implication of defective natural killer T cells.
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非段性白癜风中周围T细胞免疫表型的全身分析：有缺陷的天然杀伤T细胞的影响。
DOI：
10.1111/j.1755-148x.2012.01019.x
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发表时间：
2012-09
影响因子：
4.3
通讯作者：
Mi QS
中科院分区：
文献类型：
--
作者：
Zhou L;Li K;Shi YL;Hamzavi I;Gao TW;Henderson M;Huggins RH;Agbai O;Mahmoud B;Mi X;Lim HW;Mi QS
尽管人们普遍认为非节段性白癜风（NSV）是由黑素细胞的自身免疫性破坏引起的，但仍然缺乏对介导这种不受控制的自身反应的免疫耐受缺陷的清楚理解。在本研究中，我们系统地评估了循环调节性T（Treg）细胞，包括CD4+CD25+FoxP3+ Treg细胞和不变的自然杀伤T（iNKT）细胞，以及幼稚和记忆性CD4+和CD8+ T细胞及其细胞因子的产生，在43例进行性NSV患者的队列中，具有种族，性别和年龄匹配的健康对照。我们发现NSV和健康对照组的CD4+和CD8+ T细胞的一般免疫表型和CD4+CD25+FoxP3+ T细胞的百分比是相当的。然而，与健康对照相比，NSV患者外周血iNKT细胞的百分比显著降低。我们的数据证实了先前的观点，即外周血CD4+CD25+FoxP3+ T细胞的百分比在NSV中保持不变，并表明缺陷的iNKT细胞参与了NSV的发病机制。
Although it is widely believed that non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, a clear understanding of defects in immune tolerance, which mediate this uncontrolled self-reactivity, is still lacking. In the present study, we systemically evaluated circulating regulatory T (Treg) cells, including CD4+CD25+FoxP3+ Treg cells and invariant natural killer T (iNKT) cells, as well as naïve and memory CD4+ and CD8+ T cells and their cytokine production, in a cohort of 43 progressive NSV patients with race-, gender-, and age-matched healthy controls. We found that the general immunophenotypes of CD4+ and CD8+ T cells and the percentage of CD4+CD25+FoxP3+ Tregs were comparable between NSV and healthy controls. However, percentages of peripheral iNKT cells were significantly decreased in NSV patients compared to that in healthy controls. Our data confirm the previous notion that the percentage of peripheral CD4+CD25+FoxP3+ Tregs remains unaltered in NSV and suggests the involvement of defective iNKT cells in the pathogenesis of NSV.