Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review)
Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer (Review)
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DOI：
10.3892/ol.2015.3698
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发表时间：
2015-11-01
期刊：
影响因子：
2.9
通讯作者：
Liang, Tong
中科院分区：
文献类型：
--
作者：
Dai, Qingsong;Li, Jixia;Liang, Tong
人工海绵和反义寡核苷酸的存在旨在减少microRNA（miRNA）的可用性，一个小的非编码RNA家族，通过参与基因表达的miRNA反应元件（MRE）靶向RNA转录本，这表明miRNA也可能受到调控。携带MRE的广泛的RNA转录物，称为竞争性内源RNA（ceRNA），包括蛋白质编码信使RNA（mRNA）和非编码RNA，例如长非编码RNA、假基因和环状RNA，其竞争共同的miRNA库作为天然诱饵。这些ceRNA是共调控的，并产生大的，复杂的转录后调控网络，这涉及到许多生物过程。本综述讨论了最近的发现，涉及天然microRNA诱饵在癌症的发展。
The existence of artificial sponges and antisense oligonucleotides designed to decrease the availability of microRNAs (miRNAs), a family of small non-coding RNAs that target RNA transcripts through miRNA response elements (MREs) involved in gene expression, suggests that miRNAs may also be regulated. The wide range of RNA transcripts harboring MREs, termed competing endogenous RNAs (ceRNAs), includes protein-coding messenger RNAs (mRNAs) and non-coding RNAs, for example long non-coding RNAs, pseudogenes and circular RNAs, which compete for a common pool of miRNAs as natural decoys. These ceRNAs are co-regulated and produce large, complex posttranscriptional regulatory networks, which have been implicated in numerous biological processes. The present review discusses recent discoveries that implicate natural microRNA decoys in the development of cancer.