Prevalence of Antibodies against Seasonal Influenza A and B Viruses in Children in Netherlands
Prevalence of Antibodies against Seasonal Influenza A and B Viruses in Children in Netherlands
复制标题
DOI：
10.1128/cvi.00396-10
复制
发表时间：
2011-03-01
影响因子：
--
通讯作者：
Rimmelzwaan, G. F.
中科院分区：
文献类型：
--
作者：
Bodewes, R.;De Mutsert, G.;Rimmelzwaan, G. F.
为了深入了解儿童首次感染流感病毒的年龄，我们分析了荷兰0至7岁儿童流感病毒抗体的血清阳性率。在2006年和2007年进行的一项基于人群的横断面研究期间采集了血清样本，并使用血凝抑制试验检测了是否存在抗甲型H1 N1、甲型H3 N2和B流感病毒（代表以往流感季节中存在的病毒）的抗体。流感病毒抗体的血清阳性率在1至6个月大的儿童中高于7至12个月大的儿童，这可能反映了母源性抗体的存在。随着年龄的增长，可检测到流感病毒抗体的>1岁的研究受试者比例逐渐增加，直到他们达到6岁时，他们都有至少一种甲型流感病毒的抗体。这些发现可能对旨在保护幼儿免受季节性和/或大流行性流感病毒感染的疫苗接种策略的制定产生影响。
To gain insight into the age at which children become infected with influenza viruses for the first time, we analyzed the seroprevalence of antibodies against influenza viruses in children 0 to 7 years of age in the Netherlands. Serum samples were collected during a cross-sectional population-based study in 2006 and 2007 and were tested for the presence of antibodies against influenza A/H1N1, A/H3N2, and B viruses representative of viruses present in previous influenza seasons using the hemagglutination inhibition assay. The seroprevalence of antibodies to influenza virus was higher in children 1 to 6 months of age than in children 7 to 12 months of age, which likely reflects the presence of maternally derived antibodies. The proportion of study subjects >1 year of age with detectable antibodies against influenza viruses gradually increased with age until they reached the age of 6 years, when they all had antibodies to at least one influenza A virus. These findings may have implications for the development of vaccination strategies aiming at the protection of young children against seasonal and/or pandemic influenza virus infection.