Predictive value of coronary artery stenoses and C-reactive protein levels in patients with stable coronary artery disease
Predictive value of coronary artery stenoses and C-reactive protein levels in patients with stable coronary artery disease
复制标题
DOI：
10.1016/j.atherosclerosis.2008.08.009
复制
发表时间：
2009-05-01
期刊：
影响因子：
5.3
通讯作者：
Kaski, Juan Carlos
中科院分区：
文献类型：
--
作者：
Arroyo-Espliguero, Ramon;Avanzas, Pablo;Kaski, Juan Carlos
引言和目的：导致急性事件的冠状动脉闭塞通常发生在非严重狭窄部位。我们试图评估慢性稳定型心绞痛（CSA）患者的非阻塞性冠状动脉狭窄和C-反应蛋白（CRP）水平的预后价值。方法：我们研究了790例连续的CSA患者进行常规冠状动脉造影。在研究入组时评估了高灵敏度CRP和冠状动脉造影。采用“血管评分”（显示管腔直径至少减少50%的冠状动脉数量）和“扩展评分”（显示血管造影可检测到动脉粥样硬化的冠状动脉树比例）对血管造影冠状动脉疾病严重程度进行分级。结果：54例（6.8%）患者存在明显的左主干病变。368例患者（46.6%）接受了血运重建。71例患者（9%）至少发生了1起合并研究终点事件（不稳定型心绞痛、心肌梗死（AMI）和心源性死亡）。发生心脏不良事件的患者的血管评分（n）显著较高（2.0 [2.0-3.0] vs. 2.0 [1.0-2.0]，P
Introduction and aims: Coronary occlusions resulting in acute events often occur at the site of non-severe stenoses. We sought to assess the prognostic value of non-obstructive Coronary stenoses and C-reactive protein (CRP) levels in patients with chronic stable angina (CSA).Methods: We studied 790 consecutive patients with CSA who underwent routine coronary arteriography. High sensitivity CRP and coronary angiograms were assessed at Study entry. Angiographic coronary disease severity was graded using a "vessel score" (number of coronary arteries showing at least 50% reduction in lumen diameter) and extent of disease with an "extension score" (Proportion of the coronary artery tree showing angiographically detectable atheroma). Patients were followed Up for 1 year.Results: Significant left main stem disease was present in 54 patients (6.8%). 368 patients (46.6%) underwent revascularization. 71 patients (9%) had at least one of the events comprised in the combined Study end-point (unstable angina, myocardial infarction (AMI) and cardiac death). Patients who suffered cardiac adverse events had a significantly higher vessel score (n) (2.0 [2.0-3.0] vs. 2.0 [1.0-2.0], P