The chemotherapy of tuberculosis: past, present and future.
The chemotherapy of tuberculosis: past, present and future.
复制标题
结核病的化学疗法：过去，现在和未来。
DOI：
10.5588/ijtld.12.0083
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Davies G
中科院分区：
文献类型：
--
作者：
Mitchison D;Davies G
The history of the development of modern chemotherapy for tuberculosis (TB), largely due to the British Medical Research Council, is first described. There is a current need to shorten the duration of treatment and to prevent and cure drug-resistant disease. These aims will only be achieved if the way in which multidrug treatment prevents resistance from emerging and the reasons for the very slow response to chemotherapy are understood. Consideration of mutation rates to resistance and the size of bacterial populations in lesions makes it very unlikely that resistance would emerge spontaneously, leaving irregularity in drug taking and inadequate dosage as the main reasons for its occurrence. Slow response to treatment seems due to the presence of persister populations whose natural history is only partly known. In the future, we need to explore the persister state in patients and in experimental murine TB, and to take it into account in the design of future mouse experiments. The activity of rifamycins and pyrazinamide is being increased by a rise in rifamycin dosage and the inhalation of pyrazinoic acid. New drugs are gradually being brought into use, initially TMC207 and the nitroimadazoles, PA824 and OPC67683. They will need to be tested in new combination regimens for drug-susceptible and multi- and extensively drug-resistant disease.
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DOI：
10.1016/0041-3879(73)90035-4
发表时间：
1973-01-01
期刊：
Tubercle
影响因子：
--
作者：
AWANESS A M;MITCHISON D A
通讯作者：
MITCHISON D A
DOI：
10.5588/ijtld.10.0616
发表时间：
2011-07-01
影响因子：
4
作者：
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通讯作者：
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影响因子：
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通讯作者：
Grosset, Jacques
DOI：
10.1164/rccm.200901-0078oc
发表时间：
2009-08-01
影响因子：
24.7
作者：
Dorman, Susan E.;Johnson, John L.;Chaisson, Richard E.
通讯作者：
Chaisson, Richard E.
影响因子：
4.9
作者：
Chigutsa, Emmanuel;Visser, Marianne E.;McIlleron, Helen
通讯作者：
McIlleron, Helen