A single-item measure of health-related quality-of-life for HIV-infected patients in routine clinical care
A single-item measure of health-related quality-of-life for HIV-infected patients in routine clinical care
复制标题
DOI：
10.1089/apc.2006.20.161
复制
发表时间：
2006-03-01
影响因子：
4.9
通讯作者：
Kitahata, MM
中科院分区：
文献类型：
--
作者：
Crane, HM;Van Rompaey, SE;Kitahata, MM
健康相关生活质量(HRQL)的测量捕捉到了没有以其他方式评估的健康的维度。然而，HRQL测量是耗时的，很难纳入常规的临床护理环境。本研究的目的是评估在常规临床护理中使用单项健康状况量表(EVGGFP)评定HIV感染者健康状况的结构效度、区分能力和可行性。在城市HIV专科诊所就诊的患者完成了一项调查，评估了他们目前的症状负担、EVGGFP和7领域21项HRQL量表(HRQL-21)测量的HRQL，以及社会人口学因素(n=269)。患者主要是男性(91%)，27%的人报告有静脉吸毒史，超过一半的人接受过一些大学教育。我们使用多元回归分析来检验EVGGFP评估的HRQL与HRQL-21之间的关系。我们比较了EVGGFP和HRQL-21的区分能力，以检测CD4细胞计数、血浆HIV-1RNA水平和症状负担的差异。我们发现，EVGGFP确定的HRQL得分与HRQL-21的领域得分显著相关(调整后的R-2为0.42-0.69)。EVGGFP的区分能力与HRQL-21相当。EVGGFP在识别总体HRQL较差的患者方面具有较高的敏感性和低至中等的特异性，这些患者可能受益于对多个HRQL领域的更全面的评估。EVGGFP可用于在常规临床护理中评估艾滋病毒感染患者的健康状况，在综合HRQL评估不切实际的情况下可能有用。
Measurement of health-related quality-of-life (HRQL) captures dimensions of health not otherwise assessed. However, HRQL measurement is time-consuming and difficult to incorporate into a routine clinical care setting. The purpose of this study was to assess the construct validity, discriminative ability, and feasibility of administering a single-item health status measure (EVGGFP) of HRQL rating health as excellent, very good, good, fair, or poor among HIV-infected patients in routine clinical care. Patients attending an urban HIV specialty clinic completed a survey assessing their current symptom burden, HRQL as measured by EVGGFP and by a 7-domain, 21-item HRQL instrument (HRQL-21), and sociodemographic factors (n = 269). Patients were predominantly men (91%), 27% reported a history of intravenous drug use, and over half had some college education. We used multiple regression analysis to examine the association between HRQL assessed by EVGGFP and the HRQL-21. We compared the discriminative ability of EVGGFP and the HRQL-21 to detect differences in CD4 cell count, plasma HIV-1 RNA level, and symptom burden. We found that HRQL scores determined by EVGGFP were significantly associated with domain scores from the HRQL-21 ( adjusted R-2 0.42-0.69). The discriminative ability of EVGGFP was equivalent to that of the HRQL-21. EVGGFP had high sensitivity and low to moderate specificity in identifying patients with poor overall HRQL who might benefit from more comprehensive evaluation of multiple HRQL domains. EVGGFP can be used to assess health status among HIV-infected patients in routine clinical care and may be useful in settings in which comprehensive HRQL assessment is not practical.