CELLULAR-IMMUNITY AND THE HYPOTHALAMIC-PITUITARY AXIS IN MAJOR AFFECTIVE-DISORDER - A PRELIMINARY-STUDY
CELLULAR-IMMUNITY AND THE HYPOTHALAMIC-PITUITARY AXIS IN MAJOR AFFECTIVE-DISORDER - A PRELIMINARY-STUDY
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DOI：
10.1016/0165-1781(88)90152-7
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发表时间：
1988-07-01
影响因子：
11.3
通讯作者：
JANOWSKY, DS
中科院分区：
文献类型：
--
作者：
DARKO, DF;LUCAS, AH;JANOWSKY, DS
为了评估重度抑郁症患者的细胞免疫状态和下丘脑-垂体轴，我们检测了外周血单个核细胞，并测量了四种神经激素的血浆水平。与11名年龄、性别和种族匹配的对照组相比，11名重度抑郁症患者的T4淋巴细胞百分比增加，而豆豆蛋白（Con A）刺激的T淋巴细胞增殖减少。标记为T淋巴细胞、B淋巴细胞和自然杀伤细胞的总淋巴细胞百分比在两组中没有差异，丝裂原诱导的白介素-2的产生也没有差异。这些发现支持了抑郁症和免疫细胞功能之间相互作用的理论。
To assess cellular immune status and the hypothalamic-pituitary axis in patients with major depression, we examined peripheral blood mononuclear cells and measured the plasma levels of four neurohormones. Eleven patients with major depression had increased % of T4 lymphocytes and decreased concanavalin (Con A) stimulated T lymphocyte proliferation when compared with 11 age-, sex-, and race-matched control subjects. Percent of total lymphocytes labeled as all T lymphocytes, all B lymphocytes, and natural killer cells did not differ in the two groups, nor did mitogen-induced interleukin-2 production. These findings support theories of interaction between depression and immune cell function.