Chitosan Electrodeposition for Microrobotic Drug Delivery
Chitosan Electrodeposition for Microrobotic Drug Delivery
复制标题
DOI：
10.1002/adhm.201200409
复制
发表时间：
2013-07-01
影响因子：
10
通讯作者：
Pane, Salvador
中科院分区：
文献类型：
--
作者：
Fusco, Stefano;Chatzipirpiridis, George;Pane, Salvador
提出了一种通过共电沉积载药壳聚糖水凝胶实现磁性微器件功能化的方法。聚合物基质的特性已经在制造，形态，药物释放和响应不同的环境条件方面进行了研究。通过简单的化学后处理可以实现基体行为的改变。该系统能够以持续的方式加载和输送40-80 g cm（-2）的模型药物（亮绿色），具有不同的轮廓。壳聚糖允许pH响应行为，在微酸性条件下更快和更有效地释放，如可以存在于肿瘤或发炎组织中。一个原型的microrobot功能化的水凝胶，并提出了治疗后眼部疾病。
A method to functionalize steerable magnetic microdevices through the co-electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40-80 g cm(-2) of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases.