Age-related changes in the brain of the dog
Age-related changes in the brain of the dog
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DOI：
10.1354/vp.36-3-202
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发表时间：
1999-05-01
影响因子：
2.4
通讯作者：
Pumarola, M
中科院分区：
文献类型：
--
作者：
Borràs, D;Ferrer, I;Pumarola, M
尽管不同物种的神经系统中已经描述了许多与年龄相关的变化，但很少有作者专门研究这个话题。这些变化的知识是至关重要的兽医病理学家，谁必须区分病变的特定病理过程中所产生的正常老化的结果。采用常规染色技术（苏木精-伊红、高碘酸-希夫）、特殊染色技术（高碘酸-乌洛托品银染色）和免疫组化技术对20只8 ~ 18岁老年犬和10只青年犬的脑进行了比较，以检测胶质细胞酸性蛋白、神经丝、泛素和β-淀粉样蛋白。改变影响脑膜和脉络丛、脑膜和实质血管、神经元和神经胶质细胞。特别感兴趣的是存在葡聚糖体、脑血管淀粉样沉积、老年斑和泛素化体。一些年龄相关的变化，特别是脂褐素，葡聚糖体，β-淀粉样蛋白沉积，可能在犬认知功能障碍综合征的发病机制中发挥作用。该犬可作为研究正常衰老和人类神经退行性疾病的天然动物模型。
Although many age-related changes have been described in the nervous system of different species, few authors have specifically studied the topic. Knowledge of such changes is essential to veterinary pathologists, who must distinguish the lesions of specific pathologic processes from those arising as a result of normal aging. The brains of 20 old dogs, ranging in age from 8 to 18 years, were compared with those of 10 young dogs using routine staining techniques (hematoxilin and eosin, periodic acid-Schiff), special staining techniques (periodic acid-methenamine silver stain), and immunohistochemical techniques to detect glial fibrillary acid protein, neurofilaments, ubiquitin, and beta-amyloid. Changes affected meninges and choroid plexuses, meningeal and parenchymal vessels, neurons, and glial cells. Of special interest was the presence of polyglucosan bodies, cerebrovascular amyloid deposition, senile plaques, and ubiquitinated bodies. Some of the age-related changes found, particularly lipofuscin, polyglucosan bodies, and beta-amyloid protein deposition, may play a role in the pathogenesis of the canine cognitive dysfunction syndrome. The dog could be used as a natural animal model for the study of normal aging and human neurodegenerative diseases.