Model Investigations of Caries Inhibition by Fluoride-Releasing Dental Materials
Model Investigations of Caries Inhibition by Fluoride-Releasing Dental Materials
复制标题
含氟牙科材料抑制龋齿的模型研究
DOI：
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发表时间：
1995
影响因子：
--
通讯作者：
E. A. Glasspoole
中科院分区：
文献类型：
--
作者：
R. Erickson;E. A. Glasspoole
释放氟化物的牙科材料通常被认为可以减少或预防继发性龋齿。这方面的证据主要是轶事，主要集中在硅酸盐水泥的临床经验，以及最近的玻璃离子水泥。不幸的是，来自对照临床试验的确凿证据不足以准确确定这些材料的有效性或在何种条件下可能有效。对于通常释放较少氟化物的新材料的临床效果，人们所知的就更少了。体外模型系统已被用于研究牙齿材料对周围牙齿结构脱矿/再矿化的影响。在这些模型中显示，与不释放氟化物的材料相比，释放氟化物的材料可以减少牙本质和牙釉质的脱矿。从机理的角度来看，这是有用的，但如果没有临床“标准”来指导模型结果，就不可能确定可接受的氟化物释放水平或需要释放的时间长度。已经进行了数量有限的原位模型研究，并获得了一些氟化物剂量反应信息。这些模型更接近实际情况，也许在缺乏足够临床资料的情况下，提供了确定材料所需的氟化物释放水平的最佳方法。
Fluoride-releasing dental materials are generally believed to reduce or prevent secondary caries. The evidence for this is largely anecdotal and centers on clinical experience with silicate cements and, more recently, with glass-ionomer cements. Unfortunately, corroborating evidence from controlled clinical trials is inadequate to establish precisely how effective these materials are or under what conditions they might be effective. Even less is known about the clinical effectiveness of newer materials that, often, release less fluoride. In vitro model systems have been used to study the effects of dental materials on de/remineralization of surrounding tooth structure. Fluoride-releasing materials have been shown in these models to reduce demineralization of both enamel and dentin compared with a material that does not release fluoride. This is useful from a mechanistic standpoint, but without clinical "standards" to guide model results, it is not possible to define an acceptable level of fluoride release or the length of time such release is required. A limited number of in situ model studies has been conducted, and some fluoride dose-response information has been obtained. These models are closer to the real situation and perhaps provide the best means to define required levels of fluoride release from materials in the absence of adequate clinical information.
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玻璃离聚物和牙本质之间的中间层中的氟化碳酸磷灰石。
DOI：
10.1016/0109-5641(93)90102-v
发表时间：
1993
期刊：
Dental materials : official publication of the Academy of Dental Materials
影响因子：
--
作者：
Geiger,SB;Weiner,S
通讯作者：
Weiner,S
玻璃离聚物修复体周围体外继发龋的形成。
DOI：
--
发表时间：
1986
期刊：
Quintessence international (Berlin, Germany : 1985)
影响因子：
--
作者：
Hicks,MJ;Flaitz,CM;Silverstone,LM
通讯作者：
Silverstone,LM
牙釉质和牙骨质从玻璃离子水门汀中吸收氟化物。
影响因子：
4.2
作者：
Retief,DH;Bradley,EL;Denton,JC;Switzer,P
通讯作者：
Switzer,P
根表面玻璃离聚物修复体周围人工损伤的形成：组织学研究。
DOI：
--
发表时间：
1986
期刊：
Gerodontics
影响因子：
--
作者：
Hicks,MJ
通讯作者：
Hicks,MJ