The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe.
The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe.
复制标题
DOI：
10.3390/cells10102729
复制
发表时间：
2021-10-13
期刊：
影响因子：
6
通讯作者：
Tischkau SA
中科院分区：
文献类型：
--
作者：
Ojo ES;Tischkau SA
近年来，芳烃受体（aryl hydrocarbon receptor, AhR）作为一种配体激活的转录因子被认为参与了多种物种的衰老表型。该受体是一种高度保守的生物传感器，可被许多外源性和内源性分子激活，包括微生物群代谢物，介导多种生理和毒理学功能。大脑衰老的特征，包括神经胶质细胞激活和炎症、氧化应激增加、线粒体功能障碍和细胞衰老，增加了人类对各种神经退行性疾病的脆弱性。有趣的是，许多研究都暗示了AhR信号通路与几个物种的衰老过程和寿命有关。这篇综述概述了AhR通路对大脑中各种衰老特征的影响，以及AhR信号作为调节大脑衰老相关疾病的机制的意义。我们还探讨了AhR配体的性质如何决定大脑衰老过程中几种信号通路的结果。
In recent years, aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has been considered to be involved in aging phenotypes across several species. This receptor is a highly conserved biosensor that is activated by numerous exogenous and endogenous molecules, including microbiota metabolites, to mediate several physiological and toxicological functions. Brain aging hallmarks, which include glial cell activation and inflammation, increased oxidative stress, mitochondrial dysfunction, and cellular senescence, increase the vulnerability of humans to various neurodegenerative diseases. Interestingly, many studies have implicated AhR signaling pathways in the aging process and longevity across several species. This review provides an overview of the impact of AhR pathways on various aging hallmarks in the brain and the implications for AhR signaling as a mechanism in regulating aging-related diseases of the brain. We also explore how the nature of AhR ligands determines the outcomes of several signaling pathways in brain aging processes.
登录
查看更多内容
影响因子：
4.8
作者：
Bravo-Ferrer, Isabel;Cuartero, Maria I.;Moro, Maria A.
通讯作者：
Moro, Maria A.
DOI：
10.18632/aging.100040
发表时间：
2009-04-20
期刊：
Aging
影响因子：
--
作者：
Blagosklonny MV;Hall MN
通讯作者：
Hall MN
影响因子：
10.6
作者：
Capuron, Lucile;Schroecksnadel, Sebastian;Fuchs, Dietmar
通讯作者：
Fuchs, Dietmar
拉喹莫德减少星形胶质细胞 NF-κB 激活可防止铜宗诱导的脱髓鞘。
影响因子：
12.7
作者：
Brück W;Pförtner R;Pham T;Zhang J;Hayardeny L;Piryatinsky V;Hanisch UK;Regen T;van Rossum D;Brakelmann L;Hagemeier K;Kuhlmann T;Stadelmann C;John GR;Kramann N;Wegner C
通讯作者：
Wegner C
影响因子：
3.9
作者：
Albertolle ME;Peter Guengerich F
通讯作者：
Peter Guengerich F