Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass
Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass
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DOI：
10.1038/ijo.2011.126
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发表时间：
2012-03-01
影响因子：
4.9
通讯作者：
le Roux, C. W.
中科院分区：
文献类型：
--
作者：
Fenske, W. K.;Bueter, M.;le Roux, C. W.
背景：患者在Roux-en-Y胃旁路手术（胃旁路手术）后表现出餐后饱腹感肠激素释放升高。改变的肠道激素反应似乎在胃旁路术后食欲和体重（BW）的降低中起着重要作用。胃旁路术后体重损失不足的患者与体重损失充足的患者相比，餐后肠道激素反应减弱。胃转流术后额外给予胃肠激素的效果尚不清楚。（PYY3-36; 300 nmol kg（-1）），胰高血糖素样肽-1（GLP-1）类似物Exendin-4结果：胃转流后大鼠体重增加（P < 0.05），生长抑素类似物奥曲肽（10 μ g/kg）对胃转流后大鼠的摄食和体重的影响（P < 0.05）。
Background: Patients show an elevated postprandial satiety gut hormone release after Roux-en-Y Gastric bypass (gastric bypass). The altered gut hormone response appears to have a prominent role in the reduction of appetite and body weight (BW) after gastric bypass. Patients with insufficient BW loss after gastric bypass have an attenuated postprandial gut hormone response in comparison with patients who lost an adequate amount of BW. The effects of additional gut hormone administration after gastric bypass are unknown.Methods: The effects of peripheral administration of peptide YY3-36 (PYY3-36; 300 nmol kg(-1)), glucagon-like peptide-1 (GLP-1) analogue Exendin-4 (20 nmol kg(-1)) and somatostatin analogue octreotide (10 mu g kg(-1)) on feeding and BW were evaluated in rats after gastric bypass.Results: Gastric bypass rats weighed (P