Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions.
Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions.
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DOI：
10.1021/ol015838l
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发表时间：
2001-04
期刊：
影响因子：
5.2
通讯作者：
A. Goodman;E. Breinlinger;C. M. McIntosh;L. Grimaldi;V. Rotello
中科院分区：
文献类型：
--
作者：
A. Goodman;E. Breinlinger;C. M. McIntosh;L. Grimaldi;V. Rotello
[结构：见正文]一个模型系统已被用来研究偶极芳香系统与氧化和还原黄素的相互作用。从头计算和实验研究表明，偶极取向的主机是一个关键的决定因素识别和氧化还原行为的黄素客人。
[structure: see text] A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin guest.