4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.
4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.
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DOI：
10.1038/nn.4251
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发表时间：
2016-04
影响因子：
25
通讯作者：
Herry C
中科院分区：
文献类型：
--
作者：
Karalis N;Dejean C;Chaudun F;Khoder S;Rozeske RR;Wurtz H;Bagur S;Benchenane K;Sirota A;Courtin J;Herry C
恐惧的表达依赖于前额叶和杏仁核回路的协调活动，但在恐惧期间允许远程网络同步的机制仍然未知。通过结合细胞外记录、药理学和光遗传学操作，我们报告说，冻结（恐惧的一种行为表达）在时间上与前额叶杏仁核回路内持续的、内部产生的 4 Hz 振荡的发展同时发生。 4 Hz 振荡可预测冻结的开始和抵消，并同步前额叶-杏仁核回路。前额叶 4 Hz 振荡的光遗传学诱导协调前额叶杏仁核活动并引发恐惧行为。这些结果揭示了一种在恐惧行为期间介导前额叶-杏仁核耦合的新型持续振荡机制。
Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological, and optogenetic manipulations we report that freezing, a behavioural expression of fear, temporally coincides with the development of sustained, internally generated 4 Hz oscillations within prefrontal-amygdala circuits. 4 Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4 Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behaviour. These results unravel a novel sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behaviour.