GENERATION OF PROSTACYCLIN BY LUNGS INVIVO AND ITS RELEASE INTO ARTERIAL CIRCULATION
GENERATION OF PROSTACYCLIN BY LUNGS INVIVO AND ITS RELEASE INTO ARTERIAL CIRCULATION
复制标题
DOI：
10.1038/273765a0
复制
发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
OCETKIEWICZ, A
中科院分区：
文献类型：
--
作者：
GRYGLEWSKI, RJ;KORBUT, R;OCETKIEWICZ, A
血管壁由前列腺素内过氧化物或花生四烯酸产生抗聚集和血管扩张物质前列环素（PGI2）1，2。几种前列腺素在穿过肺循环时迅速失活3，但前列环素通过时保持不变4，5。我们在此报告前列环素是由肺在体内或体外连续产生的。显然，肺的这种内分泌样功能可能在机体对动脉内血栓形成的天然抵抗力中发挥重要作用。
VASCULAR walls generate from prostaglandin endoperoxides or arachidonic acid an anti-aggregatory and a vasodilator substance, prostacyclin (PGI2)1,2. Several prostaglandins are rapidly inactivated as they traverse the pulmonary circulation3but prostacyclin passes through unchanged4,5. We report here that prostacyclin is continuously generated by the lungsin vivoorin vitro. Clearly, such an endocrine-like function of the lungs could play an important part in the natural resistance of the organism against intra-arterial thrombosis.