Effects of menopause and nasal occlusion on breathing during sleep
Effects of menopause and nasal occlusion on breathing during sleep
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DOI：
10.1164/ajrccm.155.1.9001313
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发表时间：
1997-01-01
影响因子：
24.7
通讯作者：
Acebo, C
中科院分区：
文献类型：
--
作者：
Carskadon, MA;Bearpark, HM;Acebo, C
据报道，睡眠呼吸障碍（SDB）的患病率在绝经期妇女中增加。我们研究了31名女性（45 ~ 55岁）在夜间多导睡眠图中对夜间呼吸挑战（鼻塞）的反应。根据病史和激素测定，13例为绝经前，4例为围绝经期，14例为绝经后。鼻塞增加呼吸暂停低通气指数（AHI）（闭塞平均值= 6.6 +/- 8.0对比基线平均值= 1.6 +/- 2.6，p < 0.01）和唤醒指数（闭塞平均值= 35.1 +/- 20.1对比基线平均值= 20.7 +/- 11.6，p < 0.001），但没有改变发生呼吸事件的患者的血氧饱和度最低值（闭塞平均值= 91.8 +/- 4.2 vs基线平均值= 92.0 +/- 11.6）。月经组在AHI、唤醒指数或氧饱和度最低点方面没有差异。比较了闭塞应答者（n = 11）和无应答者（n = 20）之间的关键变量。应答者和无应答者没有通过年龄、绝经状态或几个头部测量或人体测量变量来区分。体重指数（31.1 +/- 8.5 vs 24.3 +/- 3.4，p < 0.003），颈围（34.0 +/- 2.5 vs 32.5 +/- 1.7 cm，p < 0.05），和下颌-舌骨距离（18.5 +/-3.8vs14.5 +/-5.7mmLp < 0.05）在应答者中更大。这些研究结果表明，激素因素可能是不重要的重量和面部形态在中年发展的SDB的妇女。
Prevalence of sleep-disordered breathing (SDB) is reported to increase in menopausal women. We examined response to a nocturnal respiratory challenge (nasal occlusion) during overnight polysomnography in 31 women (45 to 55 yr). Thirteen were premenopausal, four perimenopausal, and 14 postmenopausal by history and hormonal assay. Nasal occlusion increased the apnea hypopnea index (AHI) (occlusion mean = 6.6 +/- 8.0 versus baseline mean = 1.6 +/- 2.6, p < 0.01) and arousal index (occlusion mean = 35.1 +/- 20.1 versus baseline mean = 20.7 +/- 11.6, p < 0.001), but did not change the oxygen saturation nadir in those with respiratory events (occlusion mean = 91.8 +/- 4.2 versus baseline mean = 92.0 +/- 11.6). Menopausal groups did not differ on AHI, arousal index, or oxygen saturation nadir in either condition. Key variables were compared between occlusion responders (n = 11) and nonresponders (n = 20). Responders and nonresponders were not distinguished by age, menopausal status, nor several cephatometric or anthropometric variables. Body mass index (31.1 +/- 8.5 versus 24.3 +/- 3.4, p < 0.003), neck circumference (34.0 +/- 2.5 versus 32.5 +/- 1.7 cm, p < 0.05), and mandibular-hyoid distance (18.5 +/- 3.8 versus 14.5 +/- 5.7 mml p < 0.05) were greater in responders. These findings suggest hormonal factors may be less important than weight and facial morphology in midlife development of SDB in women.