SYNAPTIC VESICLE PHOSPHOPROTEINS AND REGULATION OF SYNAPTIC FUNCTION
SYNAPTIC VESICLE PHOSPHOPROTEINS AND REGULATION OF SYNAPTIC FUNCTION
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DOI：
10.1126/science.8430330
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发表时间：
1993-02-05
期刊：
影响因子：
56.9
通讯作者：
BENFENATI, F
中科院分区：
文献类型：
--
作者：
GREENGARD, P;VALTORTA, F;BENFENATI, F
复杂的大脑功能，如学习和记忆，被认为与神经细胞之间交流效率的变化有关。因此，阐明调节突触传递（细胞间通讯过程）的分子机制是理解神经系统功能的重要一步。突触囊泡是储存神经递质的细胞器，与突触囊泡相关的几种蛋白质是蛋白质磷酸化和去磷酸化的靶标。其中一种磷酸化蛋白，突触蛋白I，通过其磷酸化状态的改变，似乎可以控制突触囊泡释放的比例，从而调节神经递质释放的效率。本文描述了目前对突触素I调节神经细胞间通讯的机制的理解，并综述了与突触囊泡相关的其他磷酸化蛋白的特性和推测功能。
Complex brain functions, such as learning and memory, are believed to involve changes in the efficiency of communication between nerve cells. Therefore, the elucidation of the molecular mechanisms that regulate synaptic transmission, the process of intercellular communication, is an essential step toward understanding nervous system function. Several proteins associated with synaptic vesicles, the organelles that store neurotransmitters, are targets for protein phosphorylation and dephosphorylation. One of these phosphoproteins, synapsin I, by means of changes in its state of phosphorylation, appears to control the fraction of synaptic vesicles available for release and thereby to regulate the efficiency of neurotransmitter release. This article describes current understanding of the mechanism by which synapsin I modulates communication between nerve cells and reviews the properties and putative functions of other phosphoproteins associated with synaptic vesicles.