HIGH-FREQUENCY ULTRASONIC VOCALIZATION INDUCED BY INTRACEREBRAL GLUTAMATE IN RATS
HIGH-FREQUENCY ULTRASONIC VOCALIZATION INDUCED BY INTRACEREBRAL GLUTAMATE IN RATS
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DOI：
10.1016/0091-3057(94)90231-3
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发表时间：
1994-12-01
影响因子：
3.6
通讯作者：
BRUDZYNSKI, SM
中科院分区：
文献类型：
--
作者：
FU, XW;BRUDZYNSKI, SM
将神经兴奋剂谷氨酸直接注射到大鼠下丘脑-视前区诱发超声发声。这种发声的特点是高频率（音调）的短时间呼叫（低于60毫秒），大多数高于40 kHz，与自然情况下观察到的已知50 kHz发声相似。谷氨酸诱导的发声在16.9 ~ 67.6 μ g剂量范围内呈剂量依赖性，可通过NMDA拮抗剂MK-801局部预处理拮抗。谷氨酸剂量的增加引起了更多的叫声，并对发射超声的频率和强度有显著影响。平均声频随谷氨酸剂量的增加而增加，平均声强随谷氨酸剂量的增加而减小。另一方面，单次通话的平均持续时间和带宽并没有随着谷氨酸的剂量而显著改变。将一种类似毒蕈碱类胆碱的药物卡巴酚注射到与谷氨酸相同的大脑部位，诱导了一种不同类型的低频率和长时间的超声波发声，称为22 khz的呼叫。结果表明，高频率、短时间鸣叫（50 kHz）和低频率、长时间鸣叫（22 kHz）具有不同的神经生理和神经化学机制。
Direct injection of glutamate, a neuroexcitatory agent, into the anterior hypothalamic-preoptic area of the rat brain induced ultrasonic vocalization. This vocalization was characterized by short-duration calls (below 60 ms) of high sound frequency (pitch), mostly above 40 kHz, and was similar to the known 50-kHz vocalization observed in natural situations. The glutamate-induced vocalization was dose dependent within the dose range of 16.9-67.6 mu g and was antagonized by local pretreatment with MK-801, an NMDA antagonist. The increasing dosage of glutamate induced more calls and had a significant influence on frequency and intensity of emitted ultrasound. The average sound frequency increased whereas the mean sound intensity decreased with the dosage of glutamate. On the other hand, the mean duration of a single call and the bandwidth did not significantly change with doses of glutamate. Injection of carbachol, a muscarinic cholinomimetic agent, into the same brain sites as glutamate, induced a different type of ultrasonic vocalization with low sound frequency and long call duration, known as 22-kHz calls. The results suggest that high sound frequency, short-duration calls (50 kHz) and low sound frequency, long-duration calls (22 kHz) have different neurophysiological and neurochemical mechanisms.