Studies on congenital hereditary cataract and microphthalmia of the miniature schnauzer dog.
Studies on congenital hereditary cataract and microphthalmia of the miniature schnauzer dog.
复制标题
小型雪纳瑞犬先天性遗传性白内障和小眼症的研究。
DOI：
10.1006/bbrc.1994.2377
复制
发表时间：
1994
影响因子：
3.1
通讯作者：
Reddy,VN
中科院分区：
文献类型：
--
作者：
Shastry,BS;Reddy,VN
Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA from affected and normal dogs for possible mutations in the homeobox containing gene and myotonic dystrophy locus. The results show that there are no signs of microdeletion, insertion, point mutation and rearrangements in these loci. Although these observations cannot completely rule out the possibility of point mutations, they suggest that the above loci are unlikely to be associated with the disease.
