Relationship between Regional Body Fat Distribution and Diabetes Mellitus: 2008 to 2010 Korean National Health and Nutrition Examination Surveys.
Relationship between Regional Body Fat Distribution and Diabetes Mellitus: 2008 to 2010 Korean National Health and Nutrition Examination Surveys.
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DOI：
10.4093/dmj.2017.41.1.51
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发表时间：
2017-02
影响因子：
5.9
通讯作者：
Huh JH
中科院分区：
文献类型：
--
作者：
Choi SI;Chung D;Lim JS;Lee MY;Shin JY;Chung CH;Huh JH
本研究的目的是调查成人中局部身体脂肪分布（尤其是腿部脂肪量）与糖尿病（DM）患病率之间的关系。根据韩国国家健康和营养检查调查（2008 年至 2010 年），对 50 岁或以上的 3,181 名男性和 3,827 名绝经后女性进行了分析。使用双能 X 射线吸收测定法测量身体成分，包括肌肉质量和局部脂肪质量。随着躯干脂肪量和手臂脂肪量的增加，DM 的比值比 (OR) 较高，而随着腿部脂肪量的增加，DM 的比值比 (OR) 较低。在根据年龄调整的偏相关分析中，腿部脂肪量与男性和女性的糖化血红蛋白以及女性的空腹血糖呈负相关。腿部脂肪量与四肢骨骼肌质量和β细胞稳态模型评估呈正相关。此外，在调整混杂因素后，随着男性和女性腿部脂肪质量四分位数的增加，DM 的 OR 逐渐下降。当我们根据腿部脂肪量和腿部肌肉量的中值将参与者细分为四组时，尽管男女腿部肌肉量较小，但较高的腿部脂肪量显着降低了患糖尿病的风险（P<0.001）。脂肪量与糖尿病患病率之间的关系根据身体脂肪分布的区域不同而不同。在韩国人群中，腿部脂肪量越高，患糖尿病的风险就越低。保持腿部脂肪量对于预防糖耐量受损可能很重要。
The aim of this study was to investigate the association between regional body fat distribution, especially leg fat mass, and the prevalence of diabetes mellitus (DM) in adult populations. A total of 3,181 men and 3,827 postmenopausal women aged 50 years or older were analyzed based on Korea National Health and Nutrition Examination Surveys (2008 to 2010). Body compositions including muscle mass and regional fat mass were measured using dual-energy X-ray absorptiometry. The odds ratios (ORs) for DM was higher with increasing truncal fat mass and arm fat mass, while it was lower with increasing leg fat mass. In a partial correlation analysis adjusted for age, leg fat mass was negatively associated with glycosylated hemoglobin in both sexes and fasting glucose in women. Leg fat mass was positively correlated with appendicular skeletal muscle mass and homeostasis model assessment of β cell. In addition, after adjusting for confounding factors, the OR for DM decreased gradually with increasing leg fat mass quartiles in both genders. When we subdivided the participants into four groups based on the median values of leg fat mass and leg muscle mass, higher leg fat mass significantly lowered the risk of DM even though they have smaller leg muscle mass in both genders (P<0.001). The relationship between fat mass and the prevalence of DM is different according to regional body fat distribution. Higher leg fat mass was associated with a lower risk of DM in Korean populations. Maintaining leg fat mass may be important in preventing impaired glucose tolerance.