Cancer mortality among chemists.
Cancer mortality among chemists.
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化学家的癌症死亡率。
DOI：
10.1093/jnci/43.5.1159
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
R. W. Miller
中科院分区：
文献类型：
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作者：
F. Li;J. Fraumeni;N. Mantel;R. W. Miller
职业性接触化学物质与皮肤癌、肺癌和膀胱癌的起源有关。为了评估化学家的癌症经历，研究人员对1948年至1967年间去世的3,637名美国化学学会会员的死亡原因进行了研究。在美国，20-64岁和64岁以上这两个年龄段的男性化学家死于癌症的比例明显高于一般职业男性（P<0.001）和老年白人男性（P<0.05）。近一半的癌症死亡归因于恶性淋巴瘤和胰腺癌。尽管方法上存在缺陷，但这些发现和其他零碎的数据表明，化学制剂可能诱发人类胰腺和淋巴组织的癌症。
Occupational exposures to chemicals have been implicated in the origin of cancers of the skin, lung, and urinary bladder. To evaluate the cancer experience of chemists in general, study was made of the causes of death among 3,637 members of the American Chemical Society who died between 1948 and 1967. A significantly higher proportion of deaths from cancer was found among male chemists in the two age categories, 20–64 years and over 64 years, as compared with professional men in general (P<0.001) and the elderly white male population (P<0.05) in the United States. Nearly half the excess cancer deaths were attributed to malignant lymphoma and carcinoma of the pancreas. Despite methodologic imperfections, these findings and other fragmentary data suggest that chemical agents may induce cancers of the pancreas and lymphoid tissue in man.