White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory
White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory
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DOI：
10.1177/0271678x17719380
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发表时间：
2018-06-01
影响因子：
6.3
通讯作者：
Schroeter, Matthias L.
中科院分区：
文献类型：
--
作者：
Kynast, Jana;Lampe, Leonie;Schroeter, Matthias L.
脑白质相关白色高信号（WMH）是磁共振成像（MRI）上观察到的白色损害的表现。它们与血管危险因素和认知障碍有关。本研究在一个大型社区居住样本中调查了WMH不同阶段的认知特征;根据个体T2加权液体衰减反转恢复MRI扫描上观察到的高信号病变，对849名年龄在21至79岁之间的受试者进行了4期Fazekas量表分类。根据DSM-5的建议，认知功能的评估包括七个认知表现领域和五个主观损害领域。本研究首次探讨了与年龄相关的WMH对心理理论的影响。Fazekas组之间的差异进行了非参数分析，并计算了效应量。效应量显示，相对于健康受试者，Fazekas组1和组2的总体认知能力略有下降。Fazekas 3组的社会认知、注意力和记忆力显著下降，但个体间差异较大。WMH组报告主观认知下降。我们证明了广泛的WMH与注意力、记忆力、社会认知和主观认知表现的特定损伤相关。WMH的详细神经心理学特征为受血管性认知下降影响的患者提供了新的治疗可能性。
Age-related white matter hyperintensities (WMH) are a manifestation of white matter damage seen on magnetic resonance imaging (MRI). They are related to vascular risk factors and cognitive impairment. This study investigated the cognitive profile at different stages of WMH in a large community-dwelling sample; 849 subjects aged 21 to 79 years were classified on the 4-stage Fazekas scale according to hyperintense lesions seen on individual T2-weighted fluid-attenuated inversion recovery MRI scans. The evaluation of cognitive functioning included seven domains of cognitive performance and five domains of subjective impairment, as proposed by the DSM-5. For the first time, the impact of age-related WMH on Theory of Mind was investigated. Differences between Fazekas groups were analyzed non-parametrically and effect sizes were computed. Effect sizes revealed a slight overall cognitive decline in Fazekas groups 1 and 2 relative to healthy subjects. Fazekas group 3 presented substantial decline in social cognition, attention and memory, although characterized by a high inter-individual variability. WMH groups reported subjective cognitive decline. We demonstrate that extensive WMH are associated with specific impairment in attention, memory, social cognition, and subjective cognitive performance. The detailed neuropsychological characterization of WMH offers new therapeutic possibilities for those affected by vascular cognitive decline.