Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature.

Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature.
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b细胞急性淋巴细胞白血病患者异基因造血细胞移植后复发巴贝斯虫感染:病例报告和文献复习。

DOI:
10.1093/ofid/ofab323
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发表时间:
2021-09
影响因子:
4.2
通讯作者:
Jacobs SE
Jacobs SE
中科院分区:
医学3区
文献类型:
--
作者:
Rosenblatt J;Leung A;Baneman E;Fuller R;Taimur S;Paniz-Mondolfi AE;Malone AK;Kirkman L;Jacobs SE

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1例复发性/难治性B细胞急性淋巴细胞白血病患者在异基因造血细胞移植前发生巴贝斯虫病,同时接受阿托伐醌预防耶氏肺孢子虫肺炎。尽管接受了延长的阿托伐醌和阿奇霉素疗程,直到聚合酶链反应不再检测到全血小巴贝斯虫DNA,但她的移植后疗程因复发的巴贝斯虫病而复杂化。我们调查潜在的主机和寄生虫的特点,导致复发/持续感染。
A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.
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