WNT signals are required for the initiation of hair follicle development
WNT signals are required for the initiation of hair follicle development
复制标题
DOI：
10.1016/s1534-5807(02)00167-3
复制
发表时间：
2002-05-01
影响因子：
11.8
通讯作者：
Millar, SE
中科院分区：
文献类型：
--
作者：
Andl, T;Reddy, ST;Millar, SE
毛囊形态发生是由真皮信号启动的，该信号诱导上皮中基板的发育。为了确定卵泡发育启动是否需要 WNT 信号，我们在转基因小鼠的皮肤中异位表达了 Dickkopf 1，这是一种有效的 WNT 作用扩散抑制剂。这导致在形态或分子分化迹象之前基板形成完全失败，并在芽阶段之前阻止牙齿和乳腺发育。该表型表明皮肤中 WNT 信号传导的激活先于调节基因的局部表达和毛囊基板形成，并且是调节基因的局部表达和毛囊基板形成的启动所必需的。
Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage. This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation.