Multi-functional nanocarriers for targeted delivery of drugs and genes
Multi-functional nanocarriers for targeted delivery of drugs and genes
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DOI：
10.1016/j.jconrel.2008.04.016
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发表时间：
2008-09-10
影响因子：
10.8
通讯作者：
Amiji, Mansoor
中科院分区：
文献类型：
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作者：
Jabr-Milane, Lara;van Vlerken, Lilian;Amiji, Mansoor
在这篇评论文章中，我们描述了马萨诸塞州波士顿东北大学实验室开发的用于靶向药物和基因递送的不同纳米平台。特别强调的是纳米平台，它提供了多功能化的机会，以允许有针对性的刺激响应和/或同时战略性地递送多种药物、基因，以及治疗系统与图像对比度增强剂的组合。聚合物和脂质纳米载体可以提供多种药物递送的多功能平台，特别是增强治疗效果并克服癌症的耐药性。此外，聚合物纳米颗粒和微球口腔系统中的纳米颗粒（NiMOS）分别可用于全身和口腔基因治疗。 (C) 2008 Elsevier B.V. 保留所有权利。
In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platforms that offer opportunities for multi-functionalization to allow for targeted stimuli-responsive and/or simultaneous strategic delivery of multiple drugs, genes, as well as the combination of therapeutic systems with image contrast enhancers. Polymeric and lipid-based nanocarriers can provide versatile platforms for the delivery of multiple pharmacological agents, specifically to enhance therapeutic effect and overcome drug resistance in cancer. In addition, polymeric nanoparticles and nanoparticles-in-microsphere oral system (NiMOS) are useful for systemic and oral gene therapy, respectively. (C) 2008 Elsevier B.V. All rights reserved.