Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers.
Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers.
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发表时间：
1986-06
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通讯作者：
A. Taylor;D. Eshima;A. Fritzberg;P. Christian;S. Kasina
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作者：
A. Taylor;D. Eshima;A. Fritzberg;P. Christian;S. Kasina
动物研究表明，非异构 N3S 三酰胺硫醇配体 99mTc 巯基乙酰基三甘氨酸 (MAG3) 可以为 131I 马尿酸 (OIH) 提供令人满意的 99mTc 标记替代品。在 10 名正常志愿者中进行了连续 30 分钟的 [99mTc]MAG3 (5-10 mCi) 和 [131I]OIH (300 microCi) 成像研究，以比较图像质量、肾脏排泄、血液清除率和肾图曲线峰值高度的时间。此外，在八名志愿者中同时给予[99mTc] MAG3 (5 mCi) 和[131I]OIH (150 microCi)，以比较180 分钟的血液和血浆清除率以及尿液排泄。在连续成像研究中，[99mTc]MAG3 的血液清除率比 [131I]OIH 更快，平均清除率为 1.30 l/min，而 [131I]OIH 为 0.88 l/min（p 小于 0.05）。 30 分钟内，MAG3 注射剂量的 73% 被排出，而 [131I]OIH 的排出剂量为 66.8%。全肾和皮质肾图曲线显示 MAG3 和 [131I]OIH 达到峰值高度的时间没有显着差异。在所有受试者中，[99mTc]MAG3 图像的质量明显优于[131I]OIH。同时注射后，当在 0-30 至 0-180 分钟的多个时间间隔内测定时，[131I]OIH 的血液和血浆清除率比 MAG3 更快（p 小于或等于 0.05）。 MAG3 和 [131I]OIH 的 0-30 分钟清除率仅略高于 0-180 分钟清除率，可用于获得两种药物的有效比较。与序贯研究一样，MAG3 的 30 分钟尿液排泄量高于 [131I]OIH（73.1% 与 69.6%），但差异无统计学意义。尽管顺序和同时给药后 MAG3 清除率的差异没有得到令人满意的解释，但事实是两种清除率都很快，MAG3 和 OIH 肾图曲线非常相似，MAG3 和 OIH 的 30 分钟尿液排泄量基本相同，表明 MAG3 可能成为 [13I]OIH 的 99mTc 替代品，并且需要进一步的临床评估。
Animal studies have suggested that the nonisomeric N3S triamide mercaptide ligand, 99mTc mercaptoacetyltriglycine (MAG3), may provide a satisfactory 99mTc-labeled replacement for 131I hippurate (OIH). Sequential 30-min [99mTc]MAG3 (5-10 mCi) and [131I]OIH (300 microCi) imaging studies were performed in ten normal volunteers in order to compare the image quality, renal excretion, blood clearance, and time to peak height of the renogram curve. In addition, [99mTc] MAG3 (5 mCi) and [131I]OIH (150 microCi) were administered simultaneously in eight volunteers for comparison of 180-min blood and plasma clearances and urine excretion. In the sequential imaging studies, the blood clearance of [99mTc]MAG3 was more rapid than [131I]OIH with a mean clearance of 1.30 l/min compared with 0.88 l/min for [131I]OIH (p less than 0.05). Seventy-three percent of the injected dose of the MAG3 was excreted by 30 min compared with 66.8% for [131I]OIH. Whole kidney and cortical renogram curves showed no significant difference in the time to peak height for MAG3 and [131I]OIH. In all subjects, the quality of the [99mTc]MAG3 images were clearly superior to [131I]OIH. Following simultaneous injection, blood and plasma clearances for [131I]OIH were more rapid than MAG3 when determined for multiple time intervals from 0-30 to 0-180 min (p less than or equal to 0.05). The 0-30-min clearances of MAG3 and [131I]OIH were only slightly greater than the 0-180-min clearances and can be used to obtain valid comparisons of the two agents. As in the sequential study, 30-min urine excretion was greater for MAG3 than [131I]OIH (73.1 compared with 69.6%) but the difference was not statistically significant. Although the differences in the MAG3 clearances following sequential and simultaneous administration are not satisfactorily explained, the fact that both clearances were rapid, the MAG3 and OIH renogram curves were quite similar, and 30-min urine excretions of MAG3 and OIH were essentially identical suggests that MAG3 may become a 99mTc replacement for [13I]OIH and further clinical evaluation is warranted.