Glutamate, glutamine and glutamine synthetase in the neonatal rat brain following hypoxia
Glutamate, glutamine and glutamine synthetase in the neonatal rat brain following hypoxia
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DOI：
10.1016/0006-8993(95)01372-5
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发表时间：
1996-01-22
期刊：
影响因子：
2.9
通讯作者：
Hadjiconstantinou, M
中科院分区：
文献类型：
--
作者：
Krajnc, D;Neff, NH;Hadjiconstantinou, M
将7日龄大鼠幼鼠暴露于缺氧（8%氧气/92%氮气）3小时，可改变纹状体、额叶皮质和海马中谷氨酸（GLU）、谷氨酰胺和谷氨酰胺合成酶（GS）的活性。在低氧损伤后，GLU立即出现快速的短暂升高，随后下降，然后在6小时内恢复到对照值。谷氨酰胺含量在损伤结束后开始下降，随后上升，并在6 h内接近对照值。GS活性在缺氧后受到抑制，并在6 h内逐渐恢复到正常水平。缺氧后3个脑区GS mRNA表达均增加，24 h内恢复到对照水平。这些结果表明，缺氧改变葡萄糖代谢在未成熟的大脑。
Exposing 7-day-old rat pups to hypoxia, 8% oxygen/92% nitrogen, for 3 h alters glutamate (GLU), glutamine and glutamine synthetase (GS) activity in the striatum, frontal cortex and hippocampus. Immediately following the hypoxic insult there is a rapid transient elevation of GLU followed by a fall and then recovery to control values within 6 h. Glutamine content initially decreased after the termination of the insult, rose thereafter and approached control values within 6 h. GS activity was depressed after hypoxia and gradually returned to normal levels within 6 h. GS mRNA was increased in the three brain regions studied after hypoxia and returned to control values within 24 h. These results suggest that hypoxia alters GLU metabolism in the immature brain.