Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice
Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice
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改良逍遥散逆转异常的大脑区域同质性，对小鼠发挥抗抑郁作用
DOI：
10.1111/neup.12540
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发表时间：
2019-04-01
期刊：
影响因子：
2.3
通讯作者：
Lv, Zhiping
中科院分区：
文献类型：
--
作者：
Bi, Yanmeng;Huang, Peng;Lv, Zhiping
本研究旨在探讨中药消药散抗抑郁作用的宏观神经机制。我们分析了血氧水平依赖（BOLD）功能磁共振成像信号。为了进一步减少BOLD信号的血流动力学变化，分析区域内神经活动或时间一致性，我们采用新开发的区域均匀性（ReHo）方法来确定慢性不可预测轻度应激（CUMS）小鼠抑郁症模型的异常功能连通性，并探讨改良消药散（MXYS）在这类小鼠中的脑区域拯救作用。我们在CUMS小鼠中发现的异常ReHo与之前在抑郁症患者中发现的相同。有趣的是，MXYS只使几个边缘区域正常化，这表明这些区域在介导MXYS的抗抑郁作用中起重要作用。我们的研究结果为在抑郁症动物模型中使用ReHo分析提供了可靠的框架，并进一步为阐明MXYS的抗抑郁作用提供了新的视角。
The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level-dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOLD signals and analyze the intra-region neural activity or temporal coherence, we employed the newly developed regional homogeneity (ReHo) approach to determine aberrant functional connectivity using the chronic unpredictable mild stress (CUMS) mouse model of depression and to also explore the brain-region rescue effect of modified Xiaoyaosan (MXYS) in such mice. We found the aberrant ReHo in CUMS mice replicated previous discoveries in patients with depression. Intriguingly, MXYS only normalized several limbic regions, which suggests the essential roles of these regions in mediating the antidepressant effects of MXYS. Our results provide a reliable framework for the use of ReHo analysis with animal models of depression and further suggest a new perspective to elucidate the antidepressant effects of MXYS.