Serial analysis of renal blood flow by positron tomography with rubidium-82.
Serial analysis of renal blood flow by positron tomography with rubidium-82.
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DOI：
10.1152/ajpheart.1986.251.5.h1024
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发表时间：
1986-11
期刊：
影响因子：
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通讯作者：
N. Tamaki;C. Rabito;N. Alpert;T. Yasuda;J. Correia;M. Barlai-Kovach;M. Kanke;S. Dragotakes;H. St
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文献类型：
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作者：
N. Tamaki;C. Rabito;N. Alpert;T. Yasuda;J. Correia;M. Barlai-Kovach;M. Kanke;S. Dragotakes;H. St
为了确定在使用稳态动力学模型恒定输注铷-82（82 Rb）期间是否可以通过正电子发射断层扫描（PET）测量肾血流量，在对照（n = 10）、在轻度流量减少（n = 7）期间、在严重流量减少（n = 10）期间和在肾再灌注（n = 3）之后对10只狗进行研究。定量PET数据以确定肾的每个横截面中82 Rb（Ct）的平均浓度。在平衡扫描过程中，通过对动脉血样本进行良好计数来测量82 Rb的动脉浓度（Ca）。82 Rb肾摄取（Ct/Ca）与肾血流量呈非线性相关（r = 0.90）。82 Rb估计的流量在对照组为3.16 +/- 1.36 ml X min-1 X g-1，在轻度和重度流量减少期间分别为1.56 +/- 0.57和0.37 +/- 0.59。微球测定的流量在对照组为2.89 +/- 0.77 ml X min-1 X g-1，在轻度减少组为1.58 +/- 0.42，在重度减少组为0.27 +/- 0.49。在闭塞和再灌注模型中，闭塞期间的82 Rb估计流量为0.21 +/- 0.15 ml X min-1 X g-1，再灌注时上升至2.13 +/- 1.08。在轻度和重度流量减少期间，对侧肾脏的82 Rb估计流量分别减少3.02 +/- 1.62 ml X min-1 X g-1（63%）和2.92 +/- 0.89（61%）。我们的结论是，PET与82 Rb允许一系列定量评估肾血流。
To determine whether renal blood flow can be measured by positron-emission tomography (PET) during constant infusion of rubidium-82 (82Rb) using a steady-state kinetic model, studies were performed in 10 dogs at control (n = 10), during mild flow reduction (n = 7), during severe flow reduction (n = 10), and after reperfusion of the kidney (n = 3). PET data were quantified to determine mean concentration of 82Rb (Ct) in each transverse section of the kidney. The arterial concentration (Ca) of 82Rb was measured by well counting of arterial blood samples during the equilibrium scan. 82Rb renal uptake (Ct/Ca) correlated nonlinearly with microsphere renal blood flow according to a steady-state kinetic model (r = 0.90). 82Rb estimated flow was 3.16 +/- 1.36 ml X min-1 X g-1 at control and 1.56 +/- 0.57 and 0.37 +/- 0.59 during mild and severe flow reductions, respectively. Microsphere determined flow was 2.89 +/- 0.77 ml X min-1 X g-1 at control, 1.58 +/- 0.42 at mild reduction, and 0.27 +/- 0.49 at severe reduction. In the occlusion and reperfusion model, the 82Rb estimated flow during occlusion was 0.21 +/- 0.15 ml X min-1 X g-1 and on reperfusion went up to 2.13 +/- 1.08. The contralateral kidney demonstrated reductions in the 82Rb estimated flow of 3.02 +/- 1.62 ml X min-1 X g-1 (63%) and 2.92 +/- 0.89 (61%) during mild and severe flow reductions, respectively. We conclude that PET with 82Rb permits serial quantitative assessment of renal flood flow.