Helminth infection impacts hematopoiesis.
Helminth infection impacts hematopoiesis.
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蠕虫感染影响造血功能。
DOI：
10.1101/2023.02.10.528073
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Agathocleous,Michalis
中科院分区：
文献类型：
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作者：
Wijshake,Tobias;Wang,Jipeng;Rose3rd,Joseph;Marlar-Pavey,Madeleine;Collins3rd,JamesJ;Agathocleous,Michalis
蠕虫感染在动物中很常见。然而，蠕虫感染对造血干细胞(HSCs)和其他造血细胞功能的影响尚未得到全面的定义。在这里，我们描述了小鼠感染曼氏血吸虫的造血反应，曼氏血吸虫是一种引起血吸虫病的寄生虫。我们分析了骨髓、脾、肝、胸腺和血液中造血细胞类型的频率或数量，并观察了感染引起的多种造血细胞变化。血吸虫感染损害连续移植后骨髓HSC功能。感染肝脏中存在有功能的肝星状细胞。感染抑制了骨髓红细胞生成，增强了脾红细胞生成，这与血吸虫病患者普遍存在的贫血和脾肿大的观察结果一致。这项工作定义了对血吸虫病的造血反应，血吸虫病是一种折磨着超过2亿人的衰弱疾病，并确定了HSC功能和红细胞生成的损害。
Helminth infections are common in animals. However, the impact of a helminth infection on the function of hematopoietic stem cells (HSCs) and other hematopoietic cells has not been comprehensively defined. Here we describe the hematopoietic response to infection of mice with Schistosoma mansoni, a parasitic flatworm which causes schistosomiasis. We analyzed the frequency or number of hematopoietic cell types in the bone marrow, spleen, liver, thymus, and blood, and observed multiple hematopoietic changes caused by infection. Schistosome infection impaired bone marrow HSC function after serial transplantation. Functional HSCs were present in the infected liver. Infection blocked bone marrow erythropoiesis and augmented spleen erythropoiesis, observations consistent with the anemia and splenomegaly prevalent in schistosomiasis patients. This work defines the hematopoietic response to schistosomiasis, a debilitating disease afflicting more than 200 million people, and identifies impairments in HSC function and erythropoiesis.