The psychological impact of disclosing amyloid status to Japanese elderly: a preliminary study on asymptomatic patients with subjective cognitive decline
The psychological impact of disclosing amyloid status to Japanese elderly: a preliminary study on asymptomatic patients with subjective cognitive decline
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DOI：
10.1017/s1041610217002204
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发表时间：
2018-05-01
影响因子：
7
通讯作者：
Mimura, Masaru
中科院分区：
文献类型：
--
作者：
Wake, Taisei;Tabuchi, Hajime;Mimura, Masaru
在日本，有460万人患有痴呆症，预计到2025年，这一数字将上升到700万。淀粉样β蛋白(Aβ)正电子发射断层扫描(PET)用于临床试验或诊断患有或不伴有主观认知功能下降(SCD)的认知正常的日本人。然而，还没有关于向这类人群披露淀粉样蛋白状态的安全性的实证研究。我们对42名参与者(Aβ阳性(n=10)和阴性(n=32))进行了淀粉样PET成像。在披露前和披露后测量状态焦虑和抑郁，并在披露后测量与考试相关的痛苦。在Aβ阳性组和阴性组中，通过披露前后的平均状态焦虑和抑郁得分低于分界线。状态焦虑和抑郁不会随着时间的推移而改变，并且在不同的组之间也没有不同。在信息披露后，两组与测试相关的平均痛苦分数都在正常范围内。两组间差异无统计学意义。在短时间内，披露Aβ阳性结果并不会引起比阴性结果更大的情绪困扰。向无症状的日本成年SCD患者透露AβPET结果具有短期心理安全性。
In Japan, 4.6 million people are living with dementia and the number is expected to rise to 7 million by 2025. Amyloid-beta (A beta) positron emission tomography (PET) is used for cognitively normal Japanese people with or without subjective cognitive decline (SCD) for the purpose of clinical trials or diagnosis. Nevertheless, no empirical studies have been conducted on the safety of disclosing amyloid status to such populations. We conducted amyloid PET imaging on 42 participants (A beta positive (n = 10) and negative (n = 32)). State anxiety and depression were measured at pre- and post-disclosure, and test-related distress at post-disclosure. Mean state anxiety and depression scores were below the cut-off through pre- and post-disclosure in the A beta positive and negative groups. State anxiety and depression did not change over time and were not different between groups. Mean test-related distress scores were within normal limits at post-disclosure in both groups. No significant difference was found between groups. Disclosing A beta positive results did not cause greater mood disturbance than negative results in a short period of time. The short-term psychological safety of disclosing A beta PET results to asymptomatic Japanese adults with SCD was indicated.