Immunotherapy approaches for the treatment of diffuse midline gliomas.
Immunotherapy approaches for the treatment of diffuse midline gliomas.
复制标题
DOI：
10.1080/2162402x.2022.2124058
复制
发表时间：
2022
期刊：
影响因子：
7.2
通讯作者：
中科院分区：
文献类型：
--
作者：
弥漫性中线胶质瘤（DMG）是儿科肿瘤中高度侵袭性且普遍致命的亚组，是大多数儿童脑肿瘤死亡的原因。中位总生存期小于12个月，诊断后2年的死亡率为90%。对潜在肿瘤生物学的研究和大量的临床试验几乎没有改变一贯的不良预后。持续开发新型、有效的DMG治疗选择仍然是一个非常重要的积极研究领域。鉴于DMG不适合手术切除，仅对辐射具有有限的反应，并且对传统化疗难治，免疫疗法已成为一种有前途的替代治疗方式。本文综述了DMG的各种免疫治疗方法及其局限性。我们探讨了基于细胞的治疗、溶瘤病毒治疗或免疫病毒治疗、免疫检查点抑制和免疫调节疫苗接种策略的使用，并强调了抗GD 2 CAR-T治疗在弥漫性内源性脑桥胶质瘤（DIPG）患者中的近期临床成功。最后，我们解决了将临床前和早期临床试验数据转化为DMG患者有效标准化治疗所面临的挑战。
Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall survival is less than 12 months with a 90% mortality rate at 2 years from diagnosis. Research into the underlying tumor biology and numerous clinical trials have done little to change the invariably poor prognosis. Continued development of novel, efficacious therapeutic options for DMGs remains a critically important area of active investigation. Given that DMGs are not amenable to surgical resection, have only limited response to radiation, and are refractory to traditional chemotherapy, immunotherapy has emerged as a promising alternative treatment modality. This review summarizes the various immunotherapy-based treatments for DMG as well as their specific limitations. We explore the use of cell-based therapies, oncolytic virotherapy or immunovirotherapy, immune checkpoint inhibition, and immunomodulatory vaccination strategies, and highlight the recent clinical success of anti-GD2 CAR-T therapy in diffuse intrinsic pontine glioma (DIPG) patients. Finally, we address the challenges faced in translating preclinical and early phase clinical trial data into effective standardized treatment for DMG patients.
影响因子：
15.9
作者：
Mochizuki A;Ramakrishna S;Good Z;Patel S;Chinnasamy H;Yeom K;Schultz L;Richards R;Campen C;Reschke A;Mahdi J;Toland A;Baggot C;Mavroukakis S;Egeler E;Moon J;Landrum K;Erickson C;Rasmussen L;Barsan V;Tamaresis J;Marcy A;Kunicki M;Celones M;Ehlinger Z;Kurra S;Cornell T;Partap S;Fisher P;Grant G;Vogel H;Davis K;Feldman S;Sahaf B;Majzner R;Mackall C;Monje M
通讯作者：
Monje M