COVID-19 in older adults: What are the differences with younger patients?
COVID-19 in older adults: What are the differences with younger patients?
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DOI：
10.1111/ggi.14102
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发表时间：
2020-12-02
影响因子：
3.3
通讯作者：
Artero, Arturo
中科院分区：
文献类型：
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作者：
Gomez-Belda, Ana B.;Fernandez-Garces, Mar;Artero, Arturo
目的本研究旨在了解2019冠状病毒病（COVID-19）老年人与年轻患者相比的独特临床特征，并确定死亡的危险因素。方法对2020年3月11日至4月28日在巴伦西亚医生佩塞特大学医院（西班牙）因COVID-19连续收治的患者进行回顾性观察研究。每个病例均通过逆转录聚合酶链反应或血清学检测进行诊断。来检测抗体。从电子病历中收集每个病例的人口统计详细信息、临床特征、入院时的实验室检查结果和并发症。结果数据集包含 340 名患者。其中，152 人（44.6%）年龄>70 岁。合并症在老年群体中更为常见。意识模糊在老年人中更为常见，而发烧、咳嗽和肌痛等 COVID-19 的典型症状则不太常见。老年组血氧饱和度0.5 μg/mL、肌酐>1.5 mg/dL、乳酸脱氢酶>=250 U/L、肌酸激酶升高较高。住院期间发生急性呼吸窘迫综合征（53.3% vs 33.2%，P < 0.001）、急性肾损伤（11.8% vs 5.3%；P = 0.030）和死亡率（28.9% vs 6.5%；P < 0.001）在年龄 >70 岁的患者中更为常见。血氧饱和度 70 年。结论 患有 COVID-19 的老年人的表现更不典型，并发症更多，死亡率更高。血氧饱和度
Aim The present study aimed both to gain knowledge on the distinctive clinical characteristics of older adults with coronavirus disease 2019 (COVID-19), in comparison with those of younger patients, and to identify risk factors for mortality.Methods A retrospective observational study was carried out of patients consecutively admitted to Doctor Peset University Hospital, Valencia (Spain) for COVID-19 from 11 March to 28 April 2020. Every case was diagnosed by reverse transcription polymerase chain reaction or by serology test to detect antibodies. Demographic details, clinical characteristics, laboratory findings on admission and complications of each case were collected from electronic medical records.Results The dataset comprised 340 patients. Of them, 152 (44.6%) were aged >70 years. Comorbidities were more common in the older groups. Confusion was more common in older adults, whereas typical symptoms of COVID-19, such as fever, cough and myalgia, were less common. Oxygen saturation 0.5 mu g/mL, creatinine >1.5 mg/dL, lactate dehydrogenase >= 250 U/L and elevation of creatine kinase were higher in the older adult groups.Complications during hospitalization, such as acute respiratory distress syndrome (53.3% vs 33.2%, P < 0.001), acute kidney injury (11.8% vs 5.3%; P = 0.030) and mortality (28.9% vs 6.5%; P < 0.001) were more common in patients aged >70 years. Oxygen saturation 70 years.Conclusions Older adults with COVID-19 have more atypical presentation, more complications and higher mortality. Oxygen saturation