Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-Cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study.
Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-Cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study.
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DOI：
10.1161/jaha.120.018293
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发表时间：
2021-07-06
影响因子：
5.4
通讯作者：
Japan Multi‐Institutional Collaborative Cohort (J‐MICC) Study Group
中科院分区：
文献类型：
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作者：
Koyama T;Ozaki E;Kuriyama N;Tomida S;Yoshida T;Uehara R;Tanaka K;Hara M;Hishida A;Okada R;Kubo Y;Oze I;Koyanagi YN;Mikami H;Nakamura Y;Shimoshikiryo I;Takezaki T;Suzuki S;Otani T;Kuriki K;Takashima N;Kadota A;Arisawa K;Katsuura-Kamano S;Ikezaki H;Murata M;Takeuchi K;Wakai K;Japan Multi‐Institutional Collaborative Cohort (J‐MICC) Study Group
这项研究的目的是确定在有或没有心脏代谢性疾病(如高血压、血脂异常和糖尿病)的情况下，休闲体育活动与久坐时间和死亡率之间的关系。利用J-MICC(日本多机构协作队列)研究的数据，对的456名参与者(男性29,022，女性35,434)进行了分析。风险比(HRs)和95%的CI被用来表征全因死亡率的相对风险，以根据自我报告的高血压、血脂异常和糖尿病的COX比例风险模型来评估其与久坐时间(类别变量：≥9h/d和2小时增量)的相关性。在7.7年的随访中，共有2257名参与者死亡。在所有因素、无因素、高血压、血脂异常和糖尿病的受试者中，每增加2小时久坐时间的相对危险度分别为1.153(95%CI，1.114~1.194)、1.125(95%CI，1.074~1.179)、1.202(95%CI，1.129~1.279)、1.176(95%CI，1.087~1.273)和1.272(95%CI，1.159~1.396)。此外，根据合并的不同因素(高血压、血脂异常和糖尿病)分析时，HR随着每个附加因素的增加而增加，报告所有三种情况的参与者的HR最高，为1.417(95%CI，1.162-1.728)，独立于休闲时间的代谢等价物。久坐时间与死亡率增加之间的关联在患有高血压、血脂异常和糖尿病的患者中更强，而与大量日本人的休闲体育活动无关。
This study aimed to determine the association between sedentary time and mortality with regard to leisure‐time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. Using data from the J‐MICC (Japan Multi‐Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all‐cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2‐hour increments in exposure) according to the self‐reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow‐up. The corresponding HRs for each 2‐hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114–1.194), 1.125 (95% CI, 1.074–1.179), 1.202 (95% CI, 1.129–1.279), 1.176 (95% CI, 1.087–1.273), and 1.272 (95% CI, 1.159–1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162–1.728) independently of leisure‐time metabolic equivalents. The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure‐time physical activity in a large Japanese population.