RESPIRATORY SYMPTOMS AND PATHOPHYSIOLOGICAL EFFECTS OF OCCUPATIONAL EXPOSURE TO FORMALDEHYDE AND WOOD DUST
RESPIRATORY SYMPTOMS AND PATHOPHYSIOLOGICAL EFFECTS OF OCCUPATIONAL EXPOSURE TO FORMALDEHYDE AND WOOD DUST
复制标题
DOI：
10.5271/sjweh.1915
复制
发表时间：
1988-10-01
影响因子：
6.3
通讯作者：
WILHELMSSON, B
中科院分区：
文献类型：
--
作者：
HOLMSTROM, M;WILHELMSSON, B
近年来，由于暴露人员的健康投诉，暴露于甲醛的危害已被广泛讨论。家庭和职业暴露于甲醛是常见的。在本研究中，甲醛单独和与木尘（另一种鼻刺激物）组合对上呼吸道和下呼吸道的影响进行了研究。这些效应与暴露的持续时间和程度有关。暴露组的上呼吸道和下呼吸道不适比未暴露组更常见。暴露受试者中的鼻塞一般不能通过鼻测压测量检测到，但是，对于单独暴露于甲醛且有鼻阻塞史的组，存在显著的鼻粘膜肿胀。与对照组相比，暴露组鼻粘膜纤毛清除明显延迟，嗅觉明显降低。肺量测定显示，暴露组的用力肺活量显著降低。本研究中没有迹象表明甲醛暴露持续时间或暴露水平对症状严重程度或生理状况损害有任何影响。
The hazards of exposure to formaldehyde have been widely discussed in recent years on account of the health complaints of exposed persons. Both domestic and occupational exposure to formaldehyde is common. In the present study the effects of formaldehyde alone and in combination with wood dust, another nasal irritant, on the upper and lower respiratory tract have been investigated. The effects were correlated with the duration and degree of exposure. Discomfort from both the upper and lower airways was more frequent in the exposed group than in the unexposed group. Nasal obstruction among the exposed subjects in general could not be detected by rhinomanometric measurements, but, for the group exposed to formaldehyde alone and with a history of nasal blocking, there was significant nasal mucosal swelling. The nasal mucociliary clearance was significantly delayed, and the sense of smell was significantly reduced in the exposed groups when they were compared with the referents. Spirometry showed a significantly decreased forced vital capacity in the exposed groups. There were no signs in this investigation that duration of exposure or level of exposure to formaldehyde would have any infleunce on the severity of symptoms or the impairment of physiological conditions.