Chemical predictors of wheeze among farmer pesticide applicators in the agricultural health study
Chemical predictors of wheeze among farmer pesticide applicators in the agricultural health study
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DOI：
10.1164/ajrccm.165.5.2106074
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发表时间：
2002-03-01
影响因子：
24.7
通讯作者：
Sandler, DP
中科院分区：
文献类型：
--
作者：
Hoppin, JA;Umbach, DM;Sandler, DP
农药可能导致农民出现呼吸道症状。利用农业健康研究，一个在爱荷华州和北卡罗来纳州认证的农药施用者的大队列，我们探讨了喘息和农药使用之间的关联在过去的一年。自填式调查问卷包含关于40种目前使用的农药和农药施用方法的项目。共有20，468名年龄从16岁到88岁不等的施用者提供了完整的信息; 19%的人在过去一年中报告了喘息。Logistic回归模型控制年龄，状态，吸烟，哮喘或过敏史被用来评估个别农药和喘息之间的关联。在疑似导致喘息的农药中，百草枯、三种有机磷（敌百虫、马拉硫磷和毒死蜱）和一种硫代氨基甲酸酯（S-乙基-二丙基硫代氨基甲酸酯[EPTC]）的优势比（OR）升高。对硫磷的OR最高（1.5，95%置信区间[CI] 1.0，2.2）。毒死蜱、EPTC、百草枯和敌百虫表现出明显的剂量反应趋势。除草剂阿特拉津和甲草胺，但不是2，4-D，与喘息有关。阿特拉津具有显著的剂量反应趋势，参与者每年使用阿特拉津超过20天，OR为1.5（95% CI 1.2，1.9）。将作物和动物纳入这些模型并没有显着改变观察到的OR。这些协会，虽然很小，建议一个独立的作用，具体农药的呼吸道症状的农民。
Pesticides may contribute to respiratory symptoms among farmers. Using the Agricultural Health Study, a large cohort of certified pesticide applicators in Iowa and North Carolina, we explored the association between wheeze and pesticide use in the past year. Self-administered questionnaires contained items on 40 currently used pesticides and pesticide application practices. A total of 20,468 applicators, ranging in age from 16 to 88 years, provided complete information; 19% reported wheezing in the past year. Logistic regression models controlling for age, state, smoking, and history of asthma or atopy were used to evaluate associations between individual pesticides and wheeze. Among pesticides suspected to contribute to wheeze, paraquat, three organophosphates (parathion, malathion, and chlorpyrifos), and one thiocarbamate (S-ethyl-dipropylthiocarbamate [EPTC]) had elevated odds ratios (OR). Parathion had the highest OR (1.5, 95% confidence interval [CI] 1.0, 2.2). Chlorpyrifos, EPTC, paraquat, and parathion demonstrated significant dose-response trends. The herbicides, atrazine and alachlor, but not 2,4-D, were associated with wheeze. Atrazine had a significant dose-response trend with participants applying atrazine more than 20 days/year having an OR of 1.5 (95% CI 1.2, 1.9). Inclusion of crops and animals into these models did not significantly alter the observed OR. These associations, though small, suggest an independent role for specific pesticides in respiratory symptoms of farmers.