Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy.
Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy.
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近红外发射 CuInS/ZnS 量子点：具有内在荧光/光声成像的一体化治疗诊断纳米药物，用于肿瘤光疗
DOI：
10.1021/acsnano.6b05419
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发表时间：
2016-10-25
期刊：
影响因子：
17.1
通讯作者：
Liang XJ
中科院分区：
文献类型：
--
作者：
Lv G;Guo W;Zhang W;Zhang T;Li S;Chen S;Eltahan AS;Wang D;Wang Y;Zhang J;Wang PC;Chang J;Liang XJ
许多治疗性纳米药物（NMs）是通过将成像和治疗部分包装在一起制成的。然而，对其潜在结构不稳定性和药代动力学复杂性的担忧仍然是其临床转化的主要障碍。在此，我们展示了使用CuInS/ZnS量子点（ZCIS QDs）作为“一体化”治疗纳米药物，在定义良好的纳米结构内具有固有的成像和治疗能力。ZCIS量子点被用于多光谱光学断层扫描（MSOT）成像和协同PTT/PDT治疗。由于ZCIS量子点固有的荧光/MSOT成像能力，它们的大小依赖性分布曲线在体内肿瘤部位成功地可视化。我们的研究结果表明，较小的纳米药物（ZCIS nm -25）比较大的纳米药物（ZCIS nm -80）具有更长的肿瘤保留时间，更高的肿瘤摄取和更深的肿瘤穿透。我们还探讨了ZCIS量子点介导光致肿瘤消融的能力。我们的研究结果证实，在单次660 nm激光照射下，ZCIS NMs同时具有固有的光热和光动力效应，对肿瘤具有很高的治疗效果。综上所述，ZCIS量子点作为“all- one”多功能纳米药物，具有很高的治疗效果，并且通过成像技术无创地监测肿瘤部位定位谱，因此具有作为精密治疗纳米药物的巨大潜力。
Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability and pharmacokinetic complexity remain major obstacles to their clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as “all-in-one” theranostic nanomedicines that possess intrinsic imaging and therapeutic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) imaging and synergistic PTT/PDT therapy. Due to the intrinsic fluorescence/MSOT imaging ability of the ZCIS QDs, their size-dependent distribution profiles were successfully visualized at tumor sites in vivo. Our results showed that the smaller nanomedicines (ZCIS NMs-25) have longer tumor retention times, higher tumor uptake, and deeper tumor penetration than the larger nanomedicines (ZCIS NMs-80). The ability of ZCIS QDs to mediate photoinduced tumor ablation was also explored. Our results verified that under a single 660 nm laser irradiation, the ZCIS NMs had simultaneous inherent photothermal and photodynamic effects, resulting in high therapy efficacy against tumors. In summary, the ZCIS QDs as “all-in-one” versatile nanomedicines allow high therapeutic efficacy as well as noninvasively monitoring tumor site localization profiles by imaging techniques and thus hold great potential as precision theranostic nanomedicines.