In Vivo Comparison of Wear Particles Between Highly Crosslinked Polyethylene and Conventional Polyethylene in the Same Design of Total Knee Arthroplasties
In Vivo Comparison of Wear Particles Between Highly Crosslinked Polyethylene and Conventional Polyethylene in the Same Design of Total Knee Arthroplasties
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DOI：
10.1002/jbm.b.31458
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发表时间：
2009-11-01
影响因子：
3.4
通讯作者：
Takaoka, Kunio
中科院分区：
文献类型：
--
作者：
Iwakiri, Kentaro;Minoda, Yukihide;Takaoka, Kunio
高交联度聚乙烯(HXLPE)在体外和体内全髋关节假体研究中已被报道减少磨损。然而，HXLPE在全膝关节假体中的应用仍然存在争议。本研究的目的是比较相同设计的全膝关节假体中HXLPE和传统聚乙烯在体内产生的聚乙烯磨粒。术后1年，4个植入HXLPE假体的膝关节和3个植入传统聚乙烯假体的膝关节获得滑液。分离出聚乙烯颗粒，并用扫描电子显微镜和图像分析仪进行检测。两组膝关节内颗粒总数分别为0.28+/-0.12x10(6)和6.87+/-2.85x10(6)(P=0.040)。颗粒大小(等效圆直径)：HXPLE组为0.64±0.07微米，常规聚乙烯组为1.21±0.2.1微米(P=0.030)。粒子形状(长径比)分别为1.33+/-0.10和1.88+/-0.19(p=0.035)。HXLPE组亚微米级粒子比例大于90%，常规聚乙烯组大于55%。除聚乙烯假体材料外，两组假体的设计和材料完全相同。在术后早期，HXLPE植入物产生的磨粒比传统的聚乙烯植入物产生的磨粒更少、更小、更圆。(C)2009年威利期刊公司生物材料资源B部分：APPL生物材料91B：799-804,2009
Reduction of wear with highly crosslinked polyethylene (HXLPE) has been reported in in vitro and in vivo studies of total hip prostheses. However, use of HXLPE in total knee prostheses is still controversial. The aim of this study was to compare in vivo polyethylene wear particle generation of HXLPE with that of conventional polyethylene in total knee prostheses of the same design. Synovial fluid was obtained from four knees with HXLPE inserts and three knees with conventional polyethylene inserts at 1 year after operation. Polyethylene particles were isolated and examined using a scanning electron microscope and image analyzer. The total number of particles in each knee was 0.28 +/- 0.12 x 10(6) in HXPLE group (mean standard error) and 6.87 +/- 2.85 x 10(6) in conventional polyethylene group (p = 0.040). Particle size (equivalent circle diameter) was 0.64 +/- 0.07 mu m in HXPLE group and 1.21 +/- 0.2.1 mu m in conventional polyethylene group (p = 0.030). Particle shape (aspect ratio) was 1.33 +/- 0.10 in HXLPE and 1.88 +/- 0.19 in conventional polyethylene (p = 0.035). The percentage of particles of submicron size was greater than 90% in HXLPE group and 55% in conventional polyethylene group. Except for the material of the polyethylene insert, the design and material of prostheses were completely the same in both groups. The HXLPE insert generated fewer, smaller, and rounder polyethylene wear particles than the conventional polyethylene insert in the early stage after surgery. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 91B: 799-804, 2009