Foundational science and mechanistic insights for a shared disease model: an expert consensus : Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group.
Foundational science and mechanistic insights for a shared disease model: an expert consensus : Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group.
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DOI：
10.1007/s00192-022-05253-y
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发表时间：
2022-06
影响因子：
1.8
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中科院分区：
文献类型：
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在这本电子书的第一版中，我们提出了一个全面的审查机制的见解，围绕着在“智囊团”头脑风暴会议期间确定的优先事项（见下文）。电子书的总体目标是综合和解释现有的机制数据，并建立一个2种PFDs-POP和SUI-的共享疾病模型，这将有助于（1）进一步了解这些PFDs的发病机制，（2）认识到重要的知识差距并确定研究重点，（3）确定新的干预目标，（4）促进经济上可行的跨学科研究计划。
PurposeIn this first edition of the e-book, we present a comprehensive review of the mechanistic insights centered around the priorities identified during a “think tank” brainstorming session (see below). The overarching goal of the e-book is to synthesize and interpret the available mechanistic data and to build a shared disease model of 2 PFDs—POP and SUI—that will serve to (1) further our understanding of the pathogenesis of these PFDs,(2) recognize important knowledge gaps and pinpoint research priorities,(3) identify novel targets for interventions, and (4) facilitate economically viable cross-disciplinary research initiatives.