PRODUCTION OF PROSTANOIDS BY LEWIS RAT SCHWANN-CELLS IN-VITRO
PRODUCTION OF PROSTANOIDS BY LEWIS RAT SCHWANN-CELLS IN-VITRO
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DOI：
10.1016/0006-8993(94)91425-7
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发表时间：
1994-01-28
期刊：
影响因子：
2.9
通讯作者：
HARTUNG, HP
中科院分区：
文献类型：
--
作者：
CONSTABLE, AL;ARMATI, PJ;HARTUNG, HP
雪旺细胞可能在周围神经自身免疫炎症性疾病的发病机制中发挥作用。它们是自身免疫攻击的目标，但也可能充当抗原呈递细胞。在这里，我们研究施万细胞可能能够通过前列腺素的产生来调节 T 细胞介导的免疫的可能性。结果表明，Lewis大鼠雪旺细胞在体外产生大量的促炎和免疫调节介质、前列腺素E(2)和血栓素A(2)，因此可能影响周围神经系统内的自身免疫炎症反应。
Schwann cells may play a role in the pathogenesis of autoimmune inflammatory diseases of peripheral nerve. They are the targets of autoimmune attack but may also act as antigen presenting cells. Here we investigate the possibility that Schwann cells may be able to modulate T-cell mediated immunity via prostanoid production. The results show that Lewis rat Schwann cells in vitro generate significant amounts of the pro-inflammatory and immunoregulatory mediators, prostaglandin E(2) and thromboxane A(2) and so may influence autoimmune inflammatory reactions within the peripheral nervous system.