Effects of space flight on ovarian-hypophyseal function in postpartum rats
Effects of space flight on ovarian-hypophyseal function in postpartum rats
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DOI：
10.1530/jrf.0.1090193
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发表时间：
1997-03-01
期刊：
影响因子：
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通讯作者：
Hodson, CA
中科院分区：
文献类型：
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作者：
Burden, HW;Zary, J;Hodson, CA
在怀孕大鼠中研究了乘坐美国国家航空和航天局（美国航天局）航天飞机进行空间飞行的影响。大鼠在妊娠第9天出生，并在妊娠第20天恢复。在妊娠第20天，对大鼠单侧子宫切除，随后使其足月并阴道分娩。空间飞行对产后垂体和卵巢质量无影响。此外，空间飞行并未改变健康和闭锁的卵巢窦卵泡数量、宫内胎儿损耗、孕酮和促黄体激素（LH）的血浆浓度或垂体促卵泡激素（FSH）的含量。空间飞行显着增加血浆FSH浓度和降低垂体LH含量在产后采样时间。总的来说，这些数据表明，在妊娠着床后阶段开始并在分娩前结束的空间飞行与维持妊娠是相容的，对产后垂体参数的影响极小;然而，所检查的卵巢参数均未因空间飞行而改变。
The effect of space flight in a National Aeronautics and Space Administration (NASA) shuttle was studied in pregnant rats. Rats were launched on day 9 of gestation and recovered on day 20 of gestation. On day 20 of gestation, rats were unilaterally hysterectomized and subsequently allowed to go to term and deliver vaginally. There was no effect of space flight on pituitary and ovary mass postpartum. In addition, space flight did not alter healthy and atretic ovarian antral follicle populations, fetal wastage in utero, plasma concentrations of progesterone and luteinizing hormone (LH) or pituitary content of follicle stimulating hormone (FSH). Space flight significantly increased plasma concentrations of FSH and decreased pituitary content of LH at the postpartum sampling time. Collectively, these data show that space flight, initiated during the postimplantation period of pregnancy, and concluded before parturition, is compatible with maintenance of pregnancy and has minimal effects on postpartum hypophyseal parameters; however, none of the ovarian parameters examined was altered by space flight.