Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports
Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports
复制标题
酒精性肝硬化中与经颈静脉肝内门体分流术相关的免疫复合物膜增生性肾小球肾炎：两例病例报告
DOI：
10.1159/000464365
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发表时间：
2017
影响因子：
3.2
通讯作者：
Jose
中科院分区：
文献类型：
--
作者：
J. Hernández;Jordi Espí;R. Alis;Ana;Diego Rodríguez;Lourdes Roca;Jose
目的：报告2例经颈静脉肝内门体分流术（TIPS）治疗酒精性肝硬化患者。临床表现和干预：2例患者有酒精性肝硬化病史，并对其进行了TIPS手术。在这两个病例中，TIPS放置后4个月，观察到蛋白尿沿着免疫复合物膜增生性肾小球肾炎（MPGN）的组织学改变特征。结论：一名患者的TIPS是成功的，没有立即并发症，而另一名患者被转诊为肝肾联合移植。在这两种情况下，免疫复合物MPGN可能在TIPS放置后发展，可能是由于免疫复合物清除减少。
Objective: To report on 2 patients with alcoholic cirrhosis who were treated with transjugular intrahepatic portosystemic shunt (TIPS) placement. Clinical Presentation and Intervention: The 2 patients had a history of alcoholic cirrhosis, and TIPS surgery was performed on them. In both cases, 4 months after TIPS placement, proteinuria was observed along with histological alterations characteristic of immune complex membranoproliferative glomerulonephritis (MPGN). Conclusion: The TIPS in one patient was successful without immediate complications, while the other patient was referred for a combined liver-kidney transplant. In both cases, immune complex MPGN might have developed after TIPS placement probably due to a reduced immune complex clearance.